Department of Pediatrics, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
Department of Critical Care Medicine, The Sixth Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
Expert Rev Clin Immunol. 2024 Sep;20(9):1127-1133. doi: 10.1080/1744666X.2024.2385765. Epub 2024 Jul 31.
We aimed to explore simple and effective clinical parameters or combinations to predict coronary artery dilation and aneurysm formation in pediatric patients with Kawasaki disease (KD).
This retrospective cohort study included pediatric patients with KD from January, 2013 to December, 2022. Multiple demographic and clinical data were collected, collated, and calculated from the medical records. Then they were divided into the coronary artery dilation and aneurysm formation group or the non-coronary artery dilation and aneurysm formation group. Lymphocyte-C-reactive protein ratio (LCR) was transformed into its natural logarithm and expressed as lnLCR.
A total of 64 pediatric patients with KD were enrolled in this cohort study after 1:3 propensity score matching (PSM). For each unit increase in lnLCR, the possibility of coronary artery dilation and aneurysm formation decreased to 0.419 times the original value. The areas under the receiver operating characteristic (ROC) curves of lnLCR combined with albumin (ALB), ALB, and lnLCR to classify pediatric patients with KD into the coronary artery dilation and aneurysm formation group were 0.781, 0.692, and 0.743, respectively.
LCR combined with ALB upon admission is a promising predictor of coronary artery dilation and aneurysm formation in pediatric patients with KD.
本研究旨在探索简单有效的临床参数或组合，以预测川崎病（KD）患儿冠状动脉扩张和动脉瘤形成。
本回顾性队列研究纳入了 2013 年 1 月至 2022 年 12 月期间的儿科 KD 患者。从病历中收集、整理和计算了多项人口统计学和临床数据。然后将其分为冠状动脉扩张和动脉瘤形成组或非冠状动脉扩张和动脉瘤形成组。淋巴细胞- C 反应蛋白比值（LCR）转换为其自然对数，并表示为 lnLCR。
经过 1:3 倾向评分匹配（PSM）后，共有 64 例儿科 KD 患者纳入本队列研究。lnLCR 每增加一个单位，冠状动脉扩张和动脉瘤形成的可能性就降低到原始值的 0.419 倍。lnLCR 联合白蛋白（ALB）、ALB 和 lnLCR 对儿科 KD 患者进行分类的受试者工作特征（ROC）曲线下面积分别为 0.781、0.692 和 0.743。
入院时 LCR 联合 ALB 是预测 KD 患儿冠状动脉扩张和动脉瘤形成的有前途的指标。
