Nutrition-Associated Biomarkers in Predicting Intravenous Immunoglobulin Resistance and Coronary Artery Lesions in Kawasaki Disease: A Systematic Review and Meta-Analysis.

Several studies explored the associations of pre-albumin (PA)/albumin (ALB) and ALB-combined indicators (prognostic nutrition index [PNI], albumin-to-globulin ratio [AGR], bilirubin-to-albumin [BAR], and C-reactive protein/albumin ratio [CAR]) with intravenous immunoglobulin (IVIG) resistance and coronary artery lesions (CALs) in Kawasaki disease (KD) patients. However, the results were controversial. A meta-analysis was conducted to reconfirm their associations and predictive performance. Databases of PubMed, EMBASE, and the Cochrane library were searched. The pooled standardized mean difference (SMD) or odds ratios (ORs) assessed the association, while the pooled area under the receiver operating characteristic curve (AUC) evaluated the predictive power. Ninety-four studies were included. Overall and subgroup meta-analyses demonstrated lower ALB and higher CAR were associated with IVIG resistance (ALB: SMD = -0.61; OR = 0.83; CAR: SMD = 1.47; OR = 1.69) and CALs (ALB: SMD = -0.56; OR = 0.92; CAR: SMD = 0.52). PNI was reduced in IVIG-resistant (SMD = -0.82) and coronary artery aneurysm (SMD = -0.18) patients in subgroup analysis and high PNI predicted the decreased risk of CALs in overall analysis (OR = 0.82). ALB, CAR, and PNI were a good or fair biomarker for differentiating IVIG-resistant (CALs) from IVIG-sensitive (non-CALs) patients (AUC > 0.6 or > 0.7). PA (SMD = -0.72) and BAR (SMD = 1.10) were differential in IVIG-resistant, but not in CAL patients compared with controls. AGR was not associated with CALs ( > 0.05). In conclusion, ALB, CAR, PNI, PA, and BAR may represent promising biomarkers for the prediction of IVIG resistance and CALs in KD patients.