Metselaar H J, van Steenberge E J, Bijnen A B, Jeekel J J, van Linge B, Weimar W
Acta Orthop Scand. 1985 Oct;56(5):413-5. doi: 10.3109/17453678508994360.
The incidence of osteonecrosis was 24% in 248 patients who had received 262 kidney transplants 1971-1982. However, based only on patients at risk, i.e. alive with functioning transplants, the incidence at 1, 3 and 6 years was found to be 13, 27 and 36%; after six years no new cases were found. The relative increase in body-weight at 180 days was predictive as regards risk for osteonecrosis, while the cumulative dose of steroids was not. This suggests that individual sensitivity to steroids rather than the absolute cumulative dose is involved in the development of osteonecrosis.
在1971年至1982年间接受262次肾移植的248例患者中，骨坏死的发生率为24%。然而，仅基于有风险的患者，即移植肾功能正常且存活的患者，1年、3年和6年时的发生率分别为13%、27%和36%；6年后未发现新病例。180天时体重的相对增加可预测骨坏死风险，而类固醇的累积剂量则不能。这表明骨坏死的发生涉及个体对类固醇的敏感性而非绝对累积剂量。
