Zhang Xu, Chang Mengfan, Ni Tongtong, Zhang Xuhan, Zhao Qiang, Li Wenguang, Li Ting
Engineering Technology Research Center of Henan Province for Solar Catalysis, College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang 473061, China.
Org Lett. 2024 Aug 9;26(31):6619-6624. doi: 10.1021/acs.orglett.4c02272. Epub 2024 Jul 29.
A practical and effective nickel-catalyzed dehydrogenative [4 + 2] annulation of 1-indanones with alkynes was reported. In this protocol, nickel-catalyzed desaturation of 1-indanones and nickel hydride catalyzed coupling with alkynes were first incorporated. A cyclopentadiene-type nickel hydride species was generated in situ via β-H elimination, and they subsequently reacted with a wide variety of alkynes to afford various benzo[a]fluorenone derivatives in good yields and regioselectivity.
报道了一种实用且有效的镍催化的1-茚满酮与炔烃的脱氢[4 + 2]环化反应。在该反应中，首次将镍催化的1-茚满酮脱氢反应和氢化镍催化的与炔烃的偶联反应相结合。通过β-H消除原位生成环戊二烯型氢化镍物种，随后它们与多种炔烃反应，以良好的产率和区域选择性得到各种苯并[a]芴酮衍生物。
