Ren Changyue, Chen Shuiyan, Yuan Zeli, Fu Rui, Cui Yanbin, Ma Zhuang, Li Weizuo, Li Xinmin
College of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, 563003, China.
School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu, 213164, China.
Chemistry. 2024 Oct 8;30(56):e202402168. doi: 10.1002/chem.202402168. Epub 2024 Sep 19.
The acceptorless dehydrogenation reaction is a sustainable and atom-economical methodology in organic synthesis, resulting in the byproducts of only hydrogen or water. Herein, a robust Co-Si/CN catalyst (derived from ZIF@SiO composite) has been synthesized through a one-step assembly process via pyrolysis and etching. This catalyst has been employed for the acceptorless dehydrogenative coupling of 2-aminoalcohols with secondary alcohols, enabling efficient conversion of various substrates into desired quinoline or pyridine derivatives with a yield of up to 94 %.
无受体脱氢反应是有机合成中一种可持续且原子经济的方法，仅产生氢气或水作为副产物。在此，通过热解和蚀刻的一步组装过程合成了一种稳健的Co-Si/CN催化剂（源自ZIF@SiO复合材料）。该催化剂已用于2-氨基醇与仲醇的无受体脱氢偶联反应，能够将各种底物高效转化为所需的喹啉或吡啶衍生物，产率高达94%。
