Pyörälä K, Savolainen E, Kaukola S, Haapakoski J
Acta Med Scand Suppl. 1985;701:38-52. doi: 10.1111/j.0954-6820.1985.tb08888.x.
In the Helsinki Policemen Study based on a cohort of 982 men aged 35-64 years and free of coronary heart disease (CHD) at entry plasma insulin level (fasting, 1-hour and 2-hour plasma insulin after oral glucose load) showed during a 9 1/2-year follow-up a non-linear association to the incidence of "hard criteria" CHD events (CHD death or non-fatal myocardial infarction) with highest incidence in the top decile of plasma insulin. Plasma insulin levels showed positive correlations, besides to blood glucose levels, to body mass index, plasma triglyceride level and blood pressure and inverse correlations to leisure time physical activity and objectively measured physical fitness. In multivariate analyses the predictive value of high plasma insulin with respect to CHD risk was found to be independent of other risk factors, including blood glucose levels.
在赫尔辛基警察研究中，以982名年龄在35至64岁、入组时无冠心病（CHD）的男性为队列，血浆胰岛素水平（空腹、口服葡萄糖负荷后1小时和2小时血浆胰岛素）在9.5年的随访期间显示与“严格标准”CHD事件（CHD死亡或非致命性心肌梗死）的发生率呈非线性关联，血浆胰岛素最高十分位数组的发生率最高。血浆胰岛素水平除与血糖水平呈正相关外，还与体重指数、血浆甘油三酯水平和血压呈正相关，与休闲时间体力活动和客观测量的体能呈负相关。在多变量分析中，发现高血浆胰岛素对CHD风险的预测价值独立于其他风险因素，包括血糖水平。
