Sebastian Amal Tom, Maji Suman, Rajashekhar Mulimani, Maiti Siddhartha, Kowalczyk Rafał, Maiti Debabrata
Department of Chemistry, Indian Institute of Technology Bombay Powai, Mumbai, 400076, India.
School of Biosciences, Engineering and Technology, VIT Bhopal University Kothrikalan, Sehore, Madhya Pradesh, 466114, India.
Angew Chem Int Ed Engl. 2024 Oct 24;63(44):e202410806. doi: 10.1002/anie.202410806. Epub 2024 Sep 30.
Pd-catalysis has stood as a pivotal force in synthetic transformations for decades, maintaining its status as a paramount tool in the realm of C-H bond activation. While functionalization at proximal positions has become commonplace, achieving selective and sustainable access to distal positions continues to captivate scientific endeavors. Recently, a noteworthy trend has emerged, focusing on the utilization of non-covalent interactions to address the challenges associated with remote functionalization. The integration of these non-covalent interactions into palladium catalysis stands as a justified response to the demands of achieving selective transformations at distal positions. This review delves into the latest advancements and trends surrounding the incorporation of non-covalent interactions within the field of palladium catalysis. Furthermore, it is noteworthy to emphasize that multifunctional templates, particularly those harnessing hydrogen bonding, present an elegant and sophisticated approach to activate C-H bonds in a highly directed fashion. These templates showcase versatility and demonstrate potential applications across diverse contexts within the area of remote functionalization.
几十年来，钯催化一直是合成转化中的关键力量，在碳氢键活化领域保持着至关重要的工具地位。虽然近端位置的官能化已变得很常见，但实现对远端位置的选择性和可持续官能化仍持续吸引着科研工作。最近，出现了一个值得注意的趋势，即专注于利用非共价相互作用来应对与远程官能化相关的挑战。将这些非共价相互作用整合到钯催化中是应对在远端位置实现选择性转化需求的合理举措。本综述深入探讨了钯催化领域中围绕非共价相互作用整合的最新进展和趋势。此外，值得强调的是，多功能模板，特别是那些利用氢键的模板，提供了一种优雅而精妙的方法，以高度定向的方式活化碳氢键。这些模板展现出多功能性，并在远程官能化领域的不同情境中展示了潜在应用。
