Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
School of Chemical Engineering, Sungkyunkwan University (SKKU), Suwon 16419, Korea.
Biomater Sci. 2024 Aug 20;12(17):4483-4492. doi: 10.1039/d4bm00598h.
Ablation cancer therapy using percutaneous intra-tumoral injection of ethanol is a promising method for targeted and effective locoregional cancer therapy. Magnetic gelatin microsphere (MGM) colloidal ethanol solution is developed as a potential injectable tumor ablation agent. The MGM was fabricated by electrostatic interactions among gelatin, acrylic acid, and acrylic acid-coated iron oxide nanoparticles. The fabricated MGM was dispersed in ethanol solution to form injectable MGM colloidal ethanol solution. The MGM colloidal ethanol solution can be easily infused and undergo gelation solvent exchange from ethanol to water in an artificial tissue. Furthermore, the MGM colloidal ethanol solution allowed doxorubicin (Dox) chemo-agent loading and its sustained release upon the formation of a drug depot by gelation in artificial tissues. Our study demonstrated that locally delivered ethanol and Dox with MGM colloidal ethanol solution promoted the anti-cancer therapeutic efficacy with a significantly suppressed cancer cell recovery rate. Overall, our developed injectable MGM colloidal ethanol solution that can be transformed to a hydrogel drug depot at the injection site holds clinical potential for a new class of chemo-ablation agents.
经皮瘤内注射乙醇消融癌症疗法是一种针对局部癌症治疗的有前途的方法。磁性明胶微球（MGM）胶态乙醇溶液被开发为一种潜在的可注射肿瘤消融剂。MGM 通过明胶、丙烯酸和涂覆有丙烯酸的氧化铁纳米粒子之间的静电相互作用来制备。所制备的 MGM 分散在乙醇溶液中，形成可注射的 MGM 胶态乙醇溶液。MGM 胶态乙醇溶液可以很容易地注入，并在人工组织中从乙醇进行凝胶化溶剂交换到水。此外，MGM 胶态乙醇溶液允许阿霉素（Dox）化疗药物加载及其在人工组织中形成药物库时的持续释放通过凝胶化。我们的研究表明，局部给予乙醇和载有 MGM 胶态乙醇溶液的 Dox 通过显著抑制癌细胞恢复率来提高抗癌治疗效果。总的来说，我们开发的可注射 MGM 胶态乙醇溶液可以在注射部位转化为水凝胶药物库，为一类新的化学消融剂提供了临床潜力。
