Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering, School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, China.
Department of General Surgery, Department of Ultrasonics, Department of Interventional Radiology, Anhui No. 2 Provincial People's Hospital, Hefei, Anhui, 230041, P. R. China.
Adv Mater. 2024 Jun;36(26):e2309770. doi: 10.1002/adma.202309770. Epub 2024 Apr 19.
Percutaneous thermotherapy, a minimally invasive operational procedure, is employed in the ablation of deep tumor lesions by means of target-delivering heat. Conventional thermal ablation methods, such as radiofrequency or microwave ablation, to a certain extent, are subjected to extended ablation time as well as biosafety risks of unwanted overheating. Given its effectiveness and safety, percutaneous thermotherapy gains a fresh perspective, thanks to magnetic hyperthermia. In this respect, an injectable- and magnetic-hydrogel-construct-based thermal ablation agent is likely to be a candidate for the aforementioned clinical translation. Adopting a simple and environment-friendly strategy, a magnetic colloidal hydrogel injection is introduced by a binary system comprising super-paramagnetic FeO nanoparticles and gelatin nanoparticles. The colloidal hydrogel constructs, unlike conventional bulk hydrogel, can be easily extruded through a percutaneous needle and then self-heal in a reversible manner owing to the unique electrostatic cross-linking. The introduction of magnetic building blocks is exhibited with a rapid magnetothermal response to an alternating magnetic field. Such hydrogel injection is capable of generating heat without limitation of deep penetration. The materials achieve outstanding therapeutic results in mouse and rabbit models. These findings constitute a new class of locoregional interventional thermal therapies with minimal collateral damages.
经皮热疗是一种微创操作程序，通过靶向输送热量来消融深部肿瘤病灶。传统的热消融方法（如射频或微波消融）在一定程度上受到消融时间延长和非目标区域过热等生物安全风险的限制。由于其有效性和安全性，经皮热疗因磁致热疗而获得新的视角。在这方面，一种基于可注射和磁性水凝胶构建体的热消融剂可能是上述临床转化的候选物。采用简单且环保的策略，通过由超顺磁 FeO 纳米粒子和明胶纳米粒子组成的二元系统引入磁性胶体水凝胶注射。与传统的块状水凝胶不同，胶体水凝胶构建体可以很容易地通过经皮针挤出，然后由于独特的静电交联以可逆的方式自我修复。磁性构建体的引入表现出对交变磁场的快速磁热响应。这种水凝胶注射能够在没有深度限制的情况下产生热量。这些材料在小鼠和兔模型中取得了优异的治疗效果。这些发现构成了一类具有最小副作用的新型局部介入性热疗。
