California National Primate Research Center, University of California, Davis, California, USA.
Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis, California, USA.
J Med Primatol. 2024 Aug;53(4):e12726. doi: 10.1111/jmp.12726.
Historically, to generate Simian Retrovirus (SRV) positive control materials, we performed in vivo passage by inoculating uninfected rhesus macaques with whole blood from an SRV-1 infected (antibody and PCR positive) macaque. However, recent attempts using this approach have failed. This study reports observations and explores why it has become more difficult to transmit SRV via in vivo passage.
从历史上看，为了生成猴免疫缺陷病毒 (SRV) 阳性对照材料，我们通过用来自感染 SRV-1（抗体和 PCR 阳性）猕猴的全血接种未感染的恒河猴来进行体内传代。然而，最近使用这种方法的尝试都失败了。本研究报告了观察结果，并探讨了为什么通过体内传代更难以传播 SRV。
