无特定病原体猕猴种群：病毒检测与种群管理的原则及近期进展综述
Specific pathogen free macaque colonies: a review of principles and recent advances for viral testing and colony management.
作者信息
Yee JoAnn L, Vanderford Thomas H, Didier Elizabeth S, Gray Stanton, Lewis Anne, Roberts Jeffrey, Taylor Kerry, Bohm Rudolf P
机构信息
California National Primate Research Center, University of California, Davis, CA, USA.
Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA.
出版信息
J Med Primatol. 2016 Apr;45(2):55-78. doi: 10.1111/jmp.12209. Epub 2016 Mar 1.
Specific pathogen free (SPF) macaques provide valuable animal models for biomedical research. In 1989, the National Center for Research Resources [now Office of Research Infrastructure Programs (ORIP)] of the National Institutes of Health initiated experimental research contracts to establish and maintain SPF colonies. The derivation and maintenance of SPF macaque colonies is a complex undertaking requiring knowledge of the biology of the agents for exclusion and normal physiology and behavior of macaques, application of the latest diagnostic technology, facilitiy management, and animal husbandry. This review provides information on the biology of the four viral agents targeted for exclusion in ORIP SPF macaque colonies, describes current state-of-the-art viral diagnostic algorithms, presents data from proficiency testing of diagnostic assays between laboratories at institutions participating in the ORIP SPF program, and outlines management strategies for maintaining the integrity of SPF colonies using results of diagnostic testing as a guide to decision making.
无特定病原体（SPF）猕猴为生物医学研究提供了有价值的动物模型。1989年，美国国立卫生研究院的国家研究资源中心[现为研究基础设施项目办公室（ORIP）]启动了实验研究合同，以建立和维持SPF种群。SPF猕猴种群的衍生和维持是一项复杂的工作，需要了解要排除的病原体的生物学特性以及猕猴的正常生理和行为，应用最新的诊断技术、设施管理和动物饲养方法。本综述提供了有关ORIP SPF猕猴种群中旨在排除的四种病毒病原体的生物学信息，描述了当前最先进的病毒诊断算法，展示了参与ORIP SPF计划的各机构实验室之间诊断检测能力验证的数据，并概述了以诊断检测结果为决策指南来维持SPF种群完整性的管理策略。
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