Epidemiology Unit, Regional Health Agency of Tuscany, Florence, Italy.
Department of Medical, Surgical and Neuroscience Sciences, University of Siena, Siena, Italy.
J Viral Hepat. 2024 Oct;31(10):577-581. doi: 10.1111/jvh.13978. Epub 2024 Jul 29.
On March 31, 2022, severe acute hepatitis of unknown origin was first reported from the Royal Glasgow Children's Hospital in Scotland. According to the criteria by WHO-ECDC, a probable case of unknown acute hepatitis in children is defined as a subject under 16 years of age, who tested negative for viral hepatitis and transaminases >500 U/L, starting from the 1st of October 2021. WHO invites Member States to participate in the global effort to collect anonymized clinical data on probable cases of severe acute hepatitis of unknown aetiology. As of May 26, 2021, 650 cases were already registered on the platform worldwide, of whom at least 38 cases have required liver transplants. Several hypotheses such as previous SARS-CoV-2 infection or coinfection or infection with another virus were examined and a strong association was found between adenovirus (41F) and acute hepatitis of unknown aetiology cases. This review article summarizes the global epidemiological evidences on acute hepatitis of unknown origin in children, analysing their incidence and characteristics.
2022 年 3 月 31 日，苏格兰皇家格拉斯哥儿童医院首次报告了不明来源的严重急性肝炎。根据世卫组织-欧洲疾病预防控制中心的标准，儿童不明原因急性肝炎的疑似病例定义为年龄在 16 岁以下、2021 年 10 月 1 日起病毒肝炎检测呈阴性且转氨酶 >500U/L 的患者。世卫组织邀请会员国参与收集不明病因严重急性肝炎疑似病例的全球努力，以收集匿名临床数据。截至 2021 年 5 月 26 日，全球平台上已登记了 650 例病例，其中至少有 38 例需要进行肝移植。此前曾对 SARS-CoV-2 感染或合并感染或感染其他病毒等假设进行了检查，发现腺病毒（41F）与不明病因急性肝炎病例之间存在很强的关联。本文综述了儿童不明原因急性肝炎的全球流行病学证据，分析了其发病率和特征。
