Department of Surgery and Anatomy, School of Medicine of Ribeirao Preto, USP, Brazil.
Department of Pharmacology, School of Medicine of Ribeirão Preto, USP, Ribeirão Preto, Brazil.
Med Gas Res. 2024 Sep 1;14(3):121-126. doi: 10.4103/2045-9912.385944. Epub 2023 Sep 17.
Tumor hypoxia may compromise the results of chemotherapy for treating colorectal cancer because it stimulates angiogenesis and the release of tumor growth factors. Hyperbaric oxygen (HBO) supplementation may potentiate the effects of chemotherapy in such cases. This study aimed to assess the effect of HBO therapy combined with chemotherapy on the treatment of colorectal cancer in mice. C57BL6 mice were submitted to the intrarectal instillation of N-methyl-N-nitrosoguanidine (MNNG) and treated with 5-fluorouracil (5FU) and/or HBO therapy. The MNNG group presented the highest dysplastic crypt rate. The 5FU + HBO group presented the highest rate of apoptotic cells per dysplastic crypt. The 5FU group presented the highest expression of hypoxia-inducible factor-1 alpha and CD44. HBO therapy increased the effect of 5FU on the treatment of the experimental colorectal neoplasia in mice.
肿瘤缺氧可能会影响结直肠癌的化疗效果，因为它会刺激血管生成和肿瘤生长因子的释放。高压氧（HBO）补充可能会增强这种情况下化疗的效果。本研究旨在评估 HBO 治疗联合化疗对治疗结直肠癌的影响。C57BL6 小鼠接受直肠内灌胃 N-甲基-N-亚硝基胍（MNNG）治疗，并接受 5-氟尿嘧啶（5FU）和/或 HBO 治疗。MNNG 组表现出最高的异型隐窝率。5FU + HBO 组表现出每个异型隐窝中凋亡细胞的最高比率。5FU 组表现出最高的缺氧诱导因子-1α和 CD44 表达。HBO 治疗增加了 5FU 对实验性结直肠肿瘤的治疗效果。
