• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

高压氧与髓芯减压治疗轻度至中度股骨头缺血性坏死的回顾性比较

A retrospective comparison of hyperbaric oxygen and core decompression for mild to moderate avascular necrosis of the femoral head.

作者信息

Sun Ming, Liang Hairui, Chen Yong, Duan Siyu, Xu Rongda, Cai Zhencun

机构信息

Department of Orthopedics Surgery, The Second Affiliated Hospital of Shenyang Medical College, Shenyang, Liaoning Province, China.

Department of Orthopedic Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning Province, China.

出版信息

Med Gas Res. 2026 Mar 1;16(1):1-5. doi: 10.4103/mgr.MEDGASRES-D-24-00162. Epub 2025 Jun 28.

DOI:10.4103/mgr.MEDGASRES-D-24-00162
PMID:40580182
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12318576/
Abstract

JOURNAL/mgres/04.03/01612956-202603000-00001/figure1/v/2025-06-28T140100Z/r/image-tiff Avascular necrosis of the femoral head is a condition resulting from disrupted blood supply, leading to ischemia and bone tissue necrosis. Core decompression (CD) restores the blood supply through pressure relief, whereas hyperbaric oxygen (HBO) enhances tissue oxygenation and promotes bone repair. Their combined use may complement each other in improving blood supply, promoting bone healing, and inhibiting disease progression, thus achieving a better therapeutic effect. To assess and compare the efficacy of HBO and/or CD for treating mild to moderate femoral head avascular necrosis, a retrospective study was conducted on patients diagnosed with Ficat stage II non-traumatic osteonecrosis between January 2017 and January 2022 at the Affiliated Central Hospital of Shenyang Medical University, China. A total of 72 patients were divided into HBO, CD, and combination groups, with 24 patients in each group. After 1 year of follow-up, 90% of patients in the HBO group, 85% in the CD group, and 95% in the combination group showed satisfactory improvements in hip joint function. The SF-36 quality of life questionnaire scale scores also significantly improved in all three groups, with the combination group showing the most significant improvement. These findings suggest that HBO offers promising potential for treating non-traumatic femoral head necrosis, with efficacy similar to that of CD. The combination group showed the most significant improvement in both hip joint function and quality of life.

摘要

《mgres》/04.03/01612956 - 202603000 - 00001/figure1/v/2025 - 06 - 28T140100Z/r/image - tiff 股骨头缺血性坏死是一种由于血液供应中断导致缺血和骨组织坏死的病症。髓芯减压术(CD)通过减压来恢复血液供应,而高压氧(HBO)可增强组织氧合并促进骨修复。它们联合使用在改善血液供应、促进骨愈合以及抑制疾病进展方面可能会起到互补作用,从而取得更好的治疗效果。为了评估和比较HBO和/或CD治疗轻度至中度股骨头缺血性坏死的疗效,对2017年1月至2022年1月在中国沈阳医学院附属中心医院被诊断为Ficat II期非创伤性骨坏死的患者进行了一项回顾性研究。总共72例患者被分为HBO组、CD组和联合治疗组,每组24例。经过1年的随访,HBO组90%的患者、CD组85%的患者以及联合治疗组95%的患者髋关节功能均有令人满意的改善。所有三组的SF - 36生活质量问卷量表评分也均显著提高,联合治疗组的改善最为显著。这些结果表明,HBO在治疗非创伤性股骨头坏死方面具有广阔的潜力,其疗效与CD相似。联合治疗组在髋关节功能和生活质量方面的改善最为显著。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d90/12318576/79a608587980/MGR-16-1-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d90/12318576/79a608587980/MGR-16-1-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8d90/12318576/79a608587980/MGR-16-1-g002.jpg

相似文献

1
A retrospective comparison of hyperbaric oxygen and core decompression for mild to moderate avascular necrosis of the femoral head.高压氧与髓芯减压治疗轻度至中度股骨头缺血性坏死的回顾性比较
Med Gas Res. 2026 Mar 1;16(1):1-5. doi: 10.4103/mgr.MEDGASRES-D-24-00162. Epub 2025 Jun 28.
2
[Direct anterior craniocervical junction fenestration decompression and bone graft for the treatment of early and middle stage osteonecrosis of the femoral head: a 3-year follow-up].[直接前路颅颈交界区开窗减压及植骨治疗早中期股骨头坏死:3年随访]
Zhongguo Gu Shang. 2025 Jul 25;38(7):680-6. doi: 10.12200/j.issn.1003-0034.20250269.
3
The use of hyperbaric oxygen for avascular necrosis of the femoral head and femoral condyle: a single centre's experience over 30 years.高压氧治疗股骨头和股骨髁缺血性坏死:30 多年单中心经验。
Diving Hyperb Med. 2024 Jun 30;54(2):92-96. doi: 10.28920/dhm54.2.92-96.
4
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.系统性药理学治疗慢性斑块状银屑病:网络荟萃分析。
Cochrane Database Syst Rev. 2021 Apr 19;4(4):CD011535. doi: 10.1002/14651858.CD011535.pub4.
5
Systemic pharmacological treatments for chronic plaque psoriasis: a network meta-analysis.慢性斑块状银屑病的全身药理学治疗:一项网状荟萃分析。
Cochrane Database Syst Rev. 2017 Dec 22;12(12):CD011535. doi: 10.1002/14651858.CD011535.pub2.
6
Stem cell therapy combined with core decompression versus core decompression alone in the treatment of avascular necrosis of the femoral head: a systematic review and meta-analysis.干细胞治疗联合核心减压与单纯核心减压治疗股骨头坏死的系统评价和荟萃分析。
J Orthop Surg Res. 2023 Aug 2;18(1):560. doi: 10.1186/s13018-023-04025-8.
7
Partial femoral head replacement: a new innovative surgical technique for precise minimally invasive treatment of association research circulation osseous stage III femoral head necrosis.部分股骨头置换术:一种用于精确微创治疗骨循环III期股骨头坏死的新型创新手术技术。
BMC Musculoskelet Disord. 2025 Jul 21;26(1):695. doi: 10.1186/s12891-025-08869-5.
8
Clinical effect of hyperbaric oxygen therapy in the treatment of femoral head necrosis : A systematic review and meta-analysis.高压氧治疗股骨头坏死的临床效果:一项系统评价与荟萃分析
Orthopade. 2017 May;46(5):440-446. doi: 10.1007/s00132-016-3360-8.
9
Does Flexion Varus Osteotomy Improve Radiographic Findings Compared With Patients Treated in a Brace for Late-onset Legg-Calvé-Perthes Disease?与支具治疗的迟发性 Legg-Calvé-Perthes 病患者相比,内翻-旋转移位截骨术是否能改善影像学发现?
Clin Orthop Relat Res. 2023 Apr 1;481(4):808-819. doi: 10.1097/CORR.0000000000002450. Epub 2022 Nov 6.
10
Hyperbaric oxygen therapy for the adjunctive treatment of traumatic brain injury.高压氧疗法辅助治疗创伤性脑损伤。
Cochrane Database Syst Rev. 2012 Dec 12;12(12):CD004609. doi: 10.1002/14651858.CD004609.pub3.

本文引用的文献

1
Hyperbaric oxygen therapy alleviates intestinal and brain damage in experimental necrotizing enterocolitis.高压氧疗法可减轻实验性坏死性小肠结肠炎中的肠道和脑损伤。
Med Gas Res. 2025 Dec 1;15(4):471-477. doi: 10.4103/mgr.MEDGASRES-D-24-00108. Epub 2025 Apr 29.
2
Pathological mechanisms and related markers of steroid-induced osteonecrosis of the femoral head.激素性股骨头坏死的病理机制及相关标志物。
Ann Med. 2024 Dec;56(1):2416070. doi: 10.1080/07853890.2024.2416070. Epub 2024 Nov 12.
3
Efficacy study of platelet-rich plasma combined with core decompression and bone grafting in the treatment of early-stage avascular necrosis of the femoral head: a retrospective study.
富血小板血浆联合核心减压植骨治疗早期股骨头坏死的疗效研究:一项回顾性研究。
BMC Musculoskelet Disord. 2024 Oct 9;25(1):796. doi: 10.1186/s12891-024-07920-1.
4
Hyperbaric oxygen promotes bone regeneration by activating the mechanosensitive Piezo1 pathway in osteogenic progenitors.高压氧通过激活成骨祖细胞中的机械敏感Piezo1通路促进骨再生。
J Orthop Translat. 2024 Jul 25;48:11-24. doi: 10.1016/j.jot.2024.07.001. eCollection 2024 Sep.
5
Clinical Characteristics, Current Treatment Options, Potential Mechanisms, Biomarkers, and Therapeutic Targets in Avascular Necrosis of Femoral Head.股骨头缺血性坏死的临床特征、当前治疗选择、潜在机制、生物标志物及治疗靶点
Med Princ Pract. 2024;33(6):519-536. doi: 10.1159/000541044. Epub 2024 Aug 21.
6
Hyperbaric oxygen therapy increases the effect of 5-fluorouracil chemotherapy on experimental colorectal cancer in mice.高压氧疗法增强了 5-氟尿嘧啶化疗对实验性结直肠癌小鼠的疗效。
Med Gas Res. 2024 Sep 1;14(3):121-126. doi: 10.4103/2045-9912.385944. Epub 2023 Sep 17.
7
Advances in the Pathogenesis of Steroid-Associated Osteonecrosis of the Femoral Head.类固醇相关性股骨头坏死发病机制的研究进展。
Biomolecules. 2024 Jun 6;14(6):667. doi: 10.3390/biom14060667.
8
Regenerative therapies for femoral head necrosis in the past two decades: a systematic review and network meta-analysis.过去二十年股骨头坏死的再生治疗:系统评价与网状Meta分析
Stem Cell Res Ther. 2024 Jan 25;15(1):21. doi: 10.1186/s13287-024-03635-1.
9
The Preserved Thickness Ratio of the Femoral Head Contributes to the Collapse Predictor of Osteonecrosis.股骨头保持厚度比有助于预测骨坏死塌陷。
Orthop Surg. 2024 Feb;16(2):412-419. doi: 10.1111/os.13967. Epub 2024 Jan 3.
10
Systematic analysis of hip-preserving treatment for early osteonecrosis of the femoral head from the perspective of bibliometrics (2010-2023).基于文献计量学的早期股骨头坏死保髋治疗的系统分析(2010-2023)。
J Orthop Surg Res. 2023 Dec 13;18(1):959. doi: 10.1186/s13018-023-04435-8.