Psit-Pranveer Singh Institute of Technology (Pharmacy), Kanpur, Uttar Pradesh, India.
Department of Pharmacology, College of Pharmacy, Shri Venkateshwara University, Gajraula, India.
J Biomater Sci Polym Ed. 2024 Nov;35(16):2570-2595. doi: 10.1080/09205063.2024.2384276. Epub 2024 Jul 29.
Inulin, a naturally occurring polysaccharide derived from plants such as chicory root, has emerged as a significant ingredient in pharmaceutical sciences due to its diverse therapeutic and functional properties. This review explores the multifaceted applications of inulin, focusing on its chemical structure, sources, and mechanisms of action. Inulin's role as a prebiotic is highlighted, with particular emphasis on its ability to modulate gut microbiota, enhance gut health, and improve metabolic processes. The review also delves into the therapeutic applications of inulin, including its potential in managing metabolic health issues such as diabetes and lipid metabolism, as well as its immune-modulating properties and benefits in gastrointestinal health. Furthermore, the article examines the incorporation of inulin in drug formulation and delivery systems, discussing its use as a stabilizing agent and its impact on enhancing drug bioavailability. Innovative inulin-based delivery systems, such as nanoparticles and hydrogels, are explored for their potential in controlled release formulations. The efficacy of inulin is supported by a review of clinical studies, underscoring its benefits in managing conditions like diabetes, cardiovascular health, and gastrointestinal disorders. Safety profiles, regulatory aspects, and potential side effects are also addressed. This comprehensive review concludes with insights into future research directions and the challenges associated with the application of inulin in pharmaceutical sciences.
菊粉是一种天然存在的多糖,来源于菊苣根等植物,由于其具有多种治疗和功能特性,已成为制药科学中的重要成分。本文综述了菊粉的多方面应用,重点介绍了其化学结构、来源和作用机制。菊粉作为一种益生元的作用得到了强调,特别强调了它调节肠道菌群、增强肠道健康和改善代谢过程的能力。本文还探讨了菊粉的治疗应用,包括其在管理代谢健康问题(如糖尿病和脂质代谢)方面的潜力,以及其免疫调节特性和对胃肠道健康的益处。此外,文章还研究了菊粉在药物配方和给药系统中的应用,讨论了它作为稳定剂的用途以及对提高药物生物利用度的影响。还探索了基于菊粉的新型给药系统,如纳米粒子和水凝胶,以研究其在控释制剂中的潜在应用。通过对临床研究的回顾,证实了菊粉在管理糖尿病、心血管健康和胃肠道疾病等疾病方面的益处。本文还讨论了安全性概况、监管方面和潜在的副作用。本文最后对未来的研究方向和菊粉在制药科学中的应用所面临的挑战进行了总结。