Perveen Rimsha, Bibi Shumaila, Saleem Mohamad A, Helal Mohamed H, Afzal Adeel, Wattoo Muhammad Ahmad, Ur Rehman Aziz
Institute of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
Health Specialties, Basic Sciences and Their Applications Unit, Applied College, Muhayl Asir, King Khalid University, Abha 62529, Saudi Arabia.
J Mater Chem B. 2025 Jun 18;13(24):6949-6989. doi: 10.1039/d5tb00147a.
This review article provides an in-depth study of recent advancements in ZIF-polymer composites, focusing on their transformative potential in drug delivery systems. It also reveals their multiple advantages, including increased drug loading efficiency, controlled and sustained release, and targeted delivery capabilities. In addition, this article explores various applications of ZIFs in diverse therapeutic areas such as orthopedic, ocular, transdermal, gastrointestinal, and pulmonary drug delivery. This review also offers key insights into the synthesis approaches, current scenario, and future directions of ZIF-polymer composites, along with some aspects of critical factors such as stimuli-responsiveness, stability, and toxicity. Zeolitic imidazolate frameworks (ZIFs), a new subclass of MOFs, are synthesized from tetrahedral metal ions and imidazolate linkers. ZIFs are valued for their exceptional porosity, robust chemical stability, and thermal characteristics. They show excellent compatibility with polymers and fabrication of ZIF-polymer hybrids with high loading efficiency is achieved using methods such as synthesis, self-assembly, grafting, electrospinning, and microfluidic synthesis techniques. By consolidating knowledge of the role of ZIF-polymer hybrids in drug delivery, this article provides a valued resource for researchers and scientists seeking to revolutionize patient care through cutting-edge materials. It also emphasizes the potential of ZIF-polymer composites to redefine drug delivery systems and improve clinical outcomes, marking a significant milestone in the quest for ideal drug delivery platforms. In summary, this review emphasizes the importance of innovative ZIF-polymer materials as promising alternatives to conventional therapeutic systems, contributing to the development of advanced healthcare solutions.
这篇综述文章深入研究了沸石咪唑酯骨架（ZIF）-聚合物复合材料的最新进展，重点关注其在药物递送系统中的变革潜力。文章还揭示了它们的多重优势，包括提高药物负载效率、控制和持续释放以及靶向递送能力。此外，本文探讨了ZIF在骨科、眼科、透皮、胃肠道和肺部药物递送等不同治疗领域的各种应用。本综述还提供了关于ZIF-聚合物复合材料的合成方法、当前现状和未来方向的关键见解，以及刺激响应性、稳定性和毒性等关键因素的一些方面。沸石咪唑酯骨架（ZIF）是金属有机骨架（MOF）的一个新子类，由四面体金属离子和咪唑酯连接体合成。ZIF因其优异的孔隙率、强大的化学稳定性和热特性而受到重视。它们与聚合物具有出色的相容性，并且使用合成、自组装、接枝、静电纺丝和微流控合成技术等方法可以实现高负载效率的ZIF-聚合物杂化物的制备。通过整合关于ZIF-聚合物杂化物在药物递送中作用的知识，本文为寻求通过前沿材料革新患者护理的研究人员和科学家提供了有价值的资源。文章还强调了ZIF-聚合物复合材料重新定义药物递送系统并改善临床结果的潜力，这标志着在寻求理想药物递送平台的过程中取得了重要里程碑。总之，本综述强调了创新的ZIF-聚合物材料作为传统治疗系统有前景的替代品的重要性，有助于先进医疗保健解决方案的开发。
