Zhang Chengxin, Freddolino Lydia
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, United States of America.
Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, United States of America.
PLoS Biol. 2024 Jul 29;22(7):e3002476. doi: 10.1371/journal.pbio.3002476. eCollection 2024 Jul.
Despite the increasing number of 3D RNA structures in the Protein Data Bank, the majority of experimental RNA structures lack thorough functional annotations. As the significance of the functional roles played by noncoding RNAs becomes increasingly apparent, comprehensive annotation of RNA function is becoming a pressing concern. In response to this need, we have developed FURNA (Functions of RNAs), the first database for experimental RNA structures that aims to provide a comprehensive repository of high-quality functional annotations. These include Gene Ontology terms, Enzyme Commission numbers, ligand-binding sites, RNA families, protein-binding motifs, and cross-references to related databases. FURNA is available at https://seq2fun.dcmb.med.umich.edu/furna/ to enable quick discovery of RNA functions from their structures and sequences.
尽管蛋白质数据库中3D RNA结构的数量不断增加，但大多数实验性RNA结构缺乏全面的功能注释。随着非编码RNA所发挥的功能作用的重要性日益明显，RNA功能的全面注释正成为一个紧迫的问题。为满足这一需求，我们开发了FURNA（RNA的功能），这是首个针对实验性RNA结构的数据库，旨在提供一个高质量功能注释的综合知识库。这些注释包括基因本体术语、酶委员会编号、配体结合位点、RNA家族、蛋白质结合基序以及与相关数据库的交叉引用。可通过https://seq2fun.dcmb.med.umich.edu/furna/访问FURNA，以便从RNA的结构和序列中快速发现其功能。
