Department of Neurology, Hanyang University College of Medicine, Guri, Republic of Korea.
Department of Neurology, Inha University School of Medicine, Incheon, Republic of Korea.
Aging (Albany NY). 2022 Apr 2;14(7):2930-2944. doi: 10.18632/aging.203993.
The relationship between sleep parameters and longitudinal shortening of telomere length is unclear. This study aimed to investigate the relationship between sleep parameters and the shortening of leukocyte telomere length (LTL) over a year.
Among the participants in the validation cohort of the Korea Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease, participants who measured both baseline and follow-up (two years later) of LTL were analyzed. They were dichotomized according to the degree of LTL attrition over two years. Clinical characteristics were compared between the faster and slower LTL shortening groups (cut-off points: -0.710 kbp, = 119 each). Multivariable logistic regression analyses were performed to determine independent relationships between faster shortening of LTL length and sleep parameters.
A total of 238 participants, aged 55-88 years, were included. Participants with faster LTL shortening had a shorter duration of sleep ( = 0.013) and longer sleep latency ( = 0.007). Among the components of the PSQI, subjective measures of sleep quality, sleep latency, sleep duration, and sleep efficiency were significantly worse in participants with faster LTL shortening. Multivariate logistic regression analysis showed that sleep duration (per hour, OR = 0.831, 95% CI = 0.698-0.989), sleep latency (per minute, OR = 1.013, 95% CI = 1.002-1.024), global PSQI score (OR = 1.134, 95% CI = 1.040-1.236), shortest sleep duration (OR = 5.173, 95% CI = 1.563-17.126), and lowest sleep efficiency (OR = 7.351, 95% CI = 1.943-27.946) were independently associated with faster LTL shortening.
Poor sleep quality, specifically short sleep duration, long sleep latency, and low sleep efficiency were associated with faster longitudinal shortening of LTL.
睡眠参数与端粒长度的纵向缩短之间的关系尚不清楚。本研究旨在探讨一年内睡眠参数与白细胞端粒长度（LTL）缩短的关系。
在韩国大脑衰老研究的验证队列中，对同时测量基线和随访（两年后）LTL 的参与者进行了分析。根据两年内 LTL 损耗程度将他们分为两组。比较两组间 LTL 缩短较快者和较慢者的临床特征（截断值：-0.710 kbp，每组各 119 人）。进行多变量逻辑回归分析，以确定 LTL 长度缩短较快与睡眠参数之间的独立关系。
共纳入 238 名年龄在 55-88 岁之间的参与者。LTL 缩短较快者的睡眠时间较短（ = 0.013），入睡潜伏期较长（ = 0.007）。在 PSQI 各组成部分中，LTL 缩短较快者的睡眠质量主观评价、入睡潜伏期、睡眠时间和睡眠效率较差。多变量逻辑回归分析显示，睡眠时间（每小时，OR = 0.831，95%CI = 0.698-0.989）、入睡潜伏期（每分钟，OR = 1.013，95%CI = 1.002-1.024）、PSQI 总分（OR = 1.134，95%CI = 1.040-1.236）、最短睡眠时间（OR = 5.173，95%CI = 1.563-17.126）和最低睡眠效率（OR = 7.351，95%CI = 1.943-27.946）与 LTL 缩短较快独立相关。
较差的睡眠质量，特别是睡眠时间短、入睡潜伏期长和睡眠效率低，与 LTL 纵向缩短较快有关。
