Früh Anton, Schaller Stefan J, Faust Katharina
Anasthesiol Intensivmed Notfallmed Schmerzther. 2024 Jul;59(7-08):438-449. doi: 10.1055/a-2075-9315. Epub 2024 Jul 29.
The neurosurgical management of traumatic brain injury (TBI) plays a critical role in ensuring acute survival and mitigating secondary brain damage, which significantly impacts patients' quality of life. TBI is defined as an external force impacting the skull, leading to brain injuries and subsequent functional impairments. It is a leading cause of mortality and morbidity, particularly among young individuals. The initial clinical examination is crucial, with external signs like scalp injuries, hematomas, nasal fluid leakage, skull deformities, and neurological deficits providing important clues to injury patterns. Pupil examination is particularly critical, as mydriasis coupled with reduced consciousness may indicate an acute life-threatening increase in intracranial pressure (ICP), necessitating immediate neurosurgical intervention. TBI assessment often utilizes the Glasgow Coma Scale (GCS), classifying injuries as mild (GCS 13-15), moderate (GCS 9-12), or severe (GCS < 9). Even mild TBI can lead to long-term complications. TBI should be viewed as a disease process rather than a singular event. Primary brain damage results from shearing forces on the parenchyma, manifesting as contusions, hematomas, or diffuse axonal injury. Secondary brain damage is driven by mechanisms such as inflammation and spreading depolarizations. Treatment aims not only to secure immediate survival but also to reduce secondary injuries, with ICP management being crucial. Neurosurgical interventions are guided by cranial pathologies, with options including ICP monitoring, burr hole trepanation, craniotomy. In severe TBI cases with refractory ICP elevation, decompressive craniectomy may be performed as a last resort, significantly reducing mortality but often resulting in high morbidity and vegetative states, necessitating careful consideration of indications.
创伤性脑损伤(TBI)的神经外科治疗在确保患者急性存活和减轻继发性脑损伤方面起着关键作用,而继发性脑损伤会对患者的生活质量产生重大影响。TBI被定义为外力撞击颅骨,导致脑损伤及随后的功能障碍。它是导致死亡和发病的主要原因,在年轻人中尤为常见。初始临床检查至关重要,头皮损伤、血肿、鼻漏、颅骨畸形和神经功能缺损等外部体征可为损伤模式提供重要线索。瞳孔检查尤为关键,因为瞳孔散大伴意识减退可能表明颅内压(ICP)急性升高危及生命,需要立即进行神经外科干预。TBI评估通常采用格拉斯哥昏迷量表(GCS),将损伤分为轻度(GCS 13 - 15)、中度(GCS 9 - 12)或重度(GCS < 9)。即使是轻度TBI也可能导致长期并发症。TBI应被视为一个疾病过程而非单一事件。原发性脑损伤由实质内的剪切力引起,表现为挫伤、血肿或弥漫性轴索损伤。继发性脑损伤由炎症和扩散性去极化等机制驱动。治疗不仅旨在确保即刻存活,还旨在减少继发性损伤,其中ICP管理至关重要。神经外科干预以颅脑病变为指导,选择包括ICP监测、钻孔引流、开颅手术。在ICP升高难以控制的重度TBI病例中,减压性颅骨切除术可能作为最后手段实施,可显著降低死亡率,但往往导致高发病率和植物状态,因此需要仔细考虑适应证。