Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, Doornfontein, South Africa.
J Biophotonics. 2024 Oct;17(10):e202400191. doi: 10.1002/jbio.202400191. Epub 2024 Jul 29.
Malignant melanoma (MM) continues to claim millions of lives around the world due to its limited therapeutic alternatives. Photodynamic therapy (PDT) has gained popularity in cancer treatment due it increased potency and low off-target toxicity. Studies have pointed out that the heterogeneity of MM tumours reduces the efficacy of current therapeutic approaches, including PDT, leading to high chances of recurrences post-treatment. Accumulating evidence suggests that cannabidiol (CBD), a non-psychoactive derivative of cannabis, can synergise with various anticancer agents to increase their efficacy. However, CBD demonstrates low bioavailability, which is attributed to factors relating to poor water compatibility, poor absorption and rapid metabolism. Nanotechnology offers tools that address these issues and enhance the biological efficiency and targeted specificity of anticancer agents. Herein, we highlighted the standard therapeutic modalities of MM and their pitfalls, as well as pointed out the need for further investigation into PDT combination therapy with CBD.
由于治疗选择有限，恶性黑色素瘤（MM）仍然在全球范围内夺走了数百万人的生命。光动力疗法（PDT）因其效力增强和低脱靶毒性而在癌症治疗中受到欢迎。研究指出，MM 肿瘤的异质性降低了包括 PDT 在内的当前治疗方法的疗效，导致治疗后复发的几率很高。越来越多的证据表明，大麻的非精神活性衍生物大麻二酚（CBD）可以与各种抗癌药物协同作用，提高其疗效。然而，CBD 的生物利用度低，这归因于与水相容性差、吸收不良和快速代谢有关的因素。纳米技术提供了一些工具，可以解决这些问题，并提高抗癌药物的生物效率和靶向特异性。在此，我们强调了 MM 的标准治疗方式及其缺陷，并指出需要进一步研究 CBD 与 PDT 的联合治疗。
