Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, Guangdong, China.
Department of Infectious Diseases and Public Health, Jockey Club College of Veterinary Medicine and Life Sciences, City University of Hong Kong, Hong Kong SAR, China.
BMC Med. 2024 Jul 29;22(1):313. doi: 10.1186/s12916-024-03534-5.
Chronic pain was associated with a higher risk of mental disorders (e.g., depression and anxiety). However, the role of 24-h movement behaviors in the association remains unclear.
A total of 72,800 participants with accelerometer data and free of mental disorders from the UK Biobank were analyzed. The compositional mediation model and isotemporal substitution model were used to explore the associations between chronic pain, 24-h movement behaviors, and the incidence of overall mental disorders, depression, and anxiety.
With a median follow-up of 13.36 years, participants with chronic pain had a higher rate of incident overall mental disorders (hazard ratio (HR): 1.281, 95% confidence interval (CI): 1.219 to 1.344), anxiety (HR: 1.391, 95% CI: 1.280 to 1.536), and depression (HR: 1.703, 95% CI: 1.551 to 1.871). Increased sedentary behavior (SB) and reduced moderate-to-vigorous physical activity (MVPA) caused by chronic pain both increased the risk of mental disorders. Twenty-four-hour movement behaviors explained the relationship between chronic pain and overall mental disorders, depression, and anxiety by 10.77%, 5.70%, and 6.86%, respectively. Interaction effects were found between MVPA and chronic pain when predicting the incidence of depression and between MVPA, sleep (SLP), and chronic pain when predicting the incidence of mental disorders. People with chronic pain would recommend at least 0.5 h per day of MVPA and 7 h per day of SLP and restricting SB below 11.5 h per day.
Twenty-four-hour movement behaviors played a significant mediating role in the association between chronic pain and mental disorders. Individuals with chronic pain should engage in more MVPA, less sedentary behavior, and have 7-h sleep per day.
慢性疼痛与精神障碍（如抑郁和焦虑）的风险增加有关。然而，24 小时运动行为在这种关联中的作用尚不清楚。
使用英国生物库中 72800 名有加速度计数据且无精神障碍的参与者进行分析。采用成分中介模型和等时替代模型探讨慢性疼痛、24 小时运动行为与总体精神障碍、抑郁和焦虑发生率之间的关系。
中位随访 13.36 年后，慢性疼痛患者的总体精神障碍（风险比（HR）：1.281，95%置信区间（CI）：1.219 至 1.344）、焦虑（HR：1.391，95%CI：1.280 至 1.536）和抑郁（HR：1.703，95%CI：1.551 至 1.871）的发生率更高。慢性疼痛导致的久坐行为（SB）增加和中等至剧烈体力活动（MVPA）减少均增加了精神障碍的风险。24 小时运动行为解释了慢性疼痛与总体精神障碍、抑郁和焦虑之间的关系，分别为 10.77%、5.70%和 6.86%。还发现 MVPA 和慢性疼痛之间存在抑郁发生率的交互作用，MVPA、睡眠（SLP）和慢性疼痛之间存在精神障碍发生率的交互作用。慢性疼痛患者建议每天至少进行 0.5 小时的 MVPA 和 7 小时的 SLP，并且每天的 SB 限制在 11.5 小时以下。
24 小时运动行为在慢性疼痛与精神障碍之间的关联中起重要中介作用。患有慢性疼痛的个体应进行更多的 MVPA，减少久坐行为，并保持每天 7 小时的睡眠时间。
