2002-2016 年澳大利亚维多利亚州糖尿病酮症酸中毒趋势。

Trends in diabetic ketoacidosis in Victoria, Australia 2002-2016.

机构信息

Department of Endocrinology & Diabetes, St Vincent's Hospital Melbourne, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia.

Department of Medicine, University of Melbourne, Fitzroy, VIC, 3065, Australia.

出版信息

BMC Endocr Disord. 2024 Jul 29;24(1):128. doi: 10.1186/s12902-024-01650-0.

DOI:10.1186/s12902-024-01650-0

PMID:39075462

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11285618/

Abstract

BACKGROUND

International longitudinal studies have indicated an increasing incidence of diabetic ketoacidosis (DKA). We aim to examine the incident trends, demographic differences, length of stay and mortality for DKA in adults with type 1 diabetes (T1D) and type 2 diabetes (T2D) in Victoria, Australia from 2002 to 2016.

METHODS

Age and sex adjusted incident trends, length of stay and mortality for DKA was retrospectively obtained using the Victorian Admitted Episode Dataset between 2002 and 2016. Data for adults with T1D and T2D was obtained from the National Diabetes Services Scheme (NDSS). Joinpoint regression analysis was used to identify changes in linear trends that were described as average annual percentage change (AAPC).

RESULTS

There were 23,628 DKA presentations in Victoria between 2002 and 2016. For T1D there was an increase in DKA presentations (AAPC + 6.8%) from 2003 to 2016 and for T2D there was a decline from 2003 to 2011 (APC - 3.5%), increase from 2011 to 2014 (APC + 38.5%), and a decrease from 2014 to 2016 (APC - 20.9%). Length of stay was longer for people with T2D than T1D (P < 0.001) and the mortality rate was 0.51% for the study period.

CONCLUSIONS

DKA rates increased for T2D from 2011 to 2014 which correlates with the introduction of sodium glucose-linked transport protein 2 inhibitors. However, the aetiology for the observed increase in T1D from 2002 to 2016 remains unknown.

摘要

背景

国际纵向研究表明，糖尿病酮症酸中毒（DKA）的发病率不断上升。我们旨在检查 2002 年至 2016 年期间，澳大利亚维多利亚州 1 型糖尿病（T1D）和 2 型糖尿病（T2D）成人 DKA 的发病趋势、人口统计学差异、住院时间和死亡率。

方法

使用 2002 年至 2016 年期间的维多利亚州入院病例数据集，回顾性获得年龄和性别调整后的 DKA 发病趋势、住院时间和死亡率。T1D 和 T2D 成人的数据来自国家糖尿病服务计划（NDSS）。采用 Joinpoint 回归分析来确定线性趋势变化，并将其描述为平均年百分比变化（AAPC）。

结果

2002 年至 2016 年期间，维多利亚州共有 23628 例 DKA 就诊。T1D 的 DKA 就诊人数呈上升趋势（AAPC + 6.8%），从 2003 年到 2016 年；而 T2D 的 DKA 就诊人数从 2003 年到 2011 年呈下降趋势（APC -3.5%），从 2011 年到 2014 年呈上升趋势（APC +38.5%），从 2014 年到 2016 年呈下降趋势（APC -20.9%）。T2D 的住院时间长于 T1D（P<0.001），研究期间的死亡率为 0.51%。