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下尿路功能障碍研究网络（LURN）症状：介绍 LURN II 急迫性尿失禁表型协议。

Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN): An introduction to the Urinary Urgency Phenotyping Protocol LURN II.

机构信息

Michigan Medicine Urology, University of Michigan, Ann Arbor, Michigan, USA.

Department of Urology, University of Washington, Seattle, Washington, USA.

出版信息

Neurourol Urodyn. 2024 Nov;43(8):1800-1808. doi: 10.1002/nau.25566. Epub 2024 Jul 29.

DOI:10.1002/nau.25566
PMID:39075835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11498147/
Abstract

AIMS

The Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) is undertaking a new cohort study in LURN II including cases and controls.

METHODS

This new cohort was enrolled to specifically study urinary urgency and urgency urinary incontinence, lower urinary tract symptoms (LUTSs) that are often difficult to treat due to a lack of understanding of their phenotypes and pathophysiologies.

RESULTS

This paper will focus on the motivation for the second iteration of LURN and highlight the new research techniques and plans for more thorough phenotyping of this population.

CONCLUSIONS

This paper will outline the gaps in understanding in treating LUTSs, specifically urinary urgency.

摘要

目的

下尿路功能障碍症状研究网络（LURN）正在开展一项新的队列研究，即 LURN II，其中包括病例和对照。

方法

这项新的队列研究旨在专门研究急迫性尿失禁和急迫性尿失禁，这些下尿路症状（LUTS）由于对其表型和病理生理学的了解不足，因此通常难以治疗。

结果

本文将重点介绍 LURN 第二次迭代的动机，并强调新的研究技术和计划，以更全面地对该人群进行表型分析。

结论

本文将概述治疗 LUTS，特别是急迫性尿失禁方面的理解差距。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc31/11498147/71a9d660ff20/nihms-2027571-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc31/11498147/71a9d660ff20/nihms-2027571-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cc31/11498147/71a9d660ff20/nihms-2027571-f0001.jpg

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本文引用的文献

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The AUA/SUFU Guideline on the Diagnosis and Treatment of Idiopathic Overactive Bladder.美国泌尿外科学会/女性泌尿外科医师学会特发性膀胱过度活动症诊断和治疗指南
J Urol. 2024 Jul;212(1):11-20. doi: 10.1097/JU.0000000000003985. Epub 2024 Apr 23.
2
Phenotyping of Urinary Urgency Patients Without Urgency Incontinence, and Their Comparison to Urgency Incontinence Patients: Findings From the LURN Study.无急迫性尿失禁的急迫性尿失禁患者的表型分析及其与急迫性尿失禁患者的比较：来自 LURN 研究的结果。
J Urol. 2023 Jan;209(1):233-242. doi: 10.1097/JU.0000000000002939. Epub 2022 Sep 6.
3
Longitudinal changes in symptom-based female and male LUTS clusters.
基于症状的女性和男性 LUTS 簇的纵向变化。
Neurourol Urodyn. 2020 Jan;39(1):393-402. doi: 10.1002/nau.24219. Epub 2019 Nov 25.
4
A New Brief Clinical Assessment of Lower Urinary Tract Symptoms for Women and Men: LURN SI-10.《女性和男性下尿路症状的新简明临床评估：LURN SI-10》。
J Urol. 2020 Jan;203(1):164-170. doi: 10.1097/JU.0000000000000465. Epub 2019 Jul 31.
5
Are three-day voiding diaries feasible and reliable? Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) cohort.三日排尿日记是否可行且可靠？来自下尿路症状研究网络（LURN）队列的结果。
Neurourol Urodyn. 2019 Nov;38(8):2185-2193. doi: 10.1002/nau.24113. Epub 2019 Jul 25.
6
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