Solanki Sarita, Vig Himangi, Khatri Nidhi, Singh Bhanu Pratap, Khan Mohammad Shahid, Devgun Manish, Wal Pranay, Wal Ankita
Department of Pharmacy, University of Kota, Kota Rajasthan, India.
PSIT-Pranveer Singh Institute of Technology (Pharmacy), NH 19 Bhauti Kanpur, Uttar Pradesh, India.
Antiinflamm Antiallergy Agents Med Chem. 2025;24(1):1-25. doi: 10.2174/0118715230320007240708074939.
Inflammatory, immune, and neurodegenerative diseases constitute a category of persistent and debilitating conditions affecting millions worldwide, with intertwined pathophysiological pathways. Recent research has spotlighted naturally occurring compounds like naringenin for potential therapeutic applications across multiple ailments.
This review offers an encompassing exploration of naringenin's anti-inflammatory, immune-protective, and neuroprotective mechanisms, elucidating its pharmacological targets, signal transduction pathways, safety profile, and insights from clinical investigations.
Data for this review were amassed through the scrutiny of various published studies search engines such as PubMed and Google Scholar. Content from reputable publishers including Bentham Science, Taylor and Francis, Nature, PLOS ONE, among others, was referenced.
Naringenin exhibits substantial anti-inflammatory effects by restraining the NF-κB signaling pathway. It activates Nrf2, renowned for its anti-inflammatory properties, inducing the release of hemeoxynase-1 by macrophages. Furthermore, naringenin treatment downregulates the expression of Th1 cytokines and inflammatory mediators. It also impedes xanthine oxidase, counteracts reactive oxygen species (ROS), scavenges superoxide radicals, mitigates the accessibility of oxygen-induced K+ erythrocytes, and reduces lipid peroxidation. Naringenin's antioxidant prowess holds promise for addressing neurological conditions.
Extensive research has been undertaken to establish the anti-inflammatory, immunomodulatory, and neuroprotective attributes of naringenin across various medical domains, lending credence to its pharmacological utility. The principal obstacle to naringenin's adoption as a therapeutic agent remains the dearth of in vivo data. Efforts should focus on rendering naringenin delivery patient-friendly, economically viable, and technologically advanced.
炎症性、免疫性和神经退行性疾病是一类持续且使人衰弱的病症，影响着全球数百万人，其病理生理途径相互交织。最近的研究聚焦于天然存在的化合物，如柚皮素，其在多种疾病中具有潜在的治疗应用。
本综述全面探讨了柚皮素的抗炎、免疫保护和神经保护机制，阐明其药理靶点、信号转导途径、安全性概况以及临床研究的见解。
本综述的数据通过对各种已发表研究的审查收集，使用了诸如PubMed和谷歌学术等搜索引擎。引用了包括本特姆科学出版社、泰勒与弗朗西斯出版社、自然出版集团、公共科学图书馆·综合等知名出版社的内容。
柚皮素通过抑制核因子κB信号通路发挥显著的抗炎作用。它激活以其抗炎特性而闻名的核因子E2相关因子2，诱导巨噬细胞释放血红素加氧酶-1。此外，柚皮素处理下调Th1细胞因子和炎症介质的表达。它还抑制黄嘌呤氧化酶，对抗活性氧，清除超氧自由基，减轻氧诱导的红细胞钾离子通透性，并减少脂质过氧化。柚皮素的抗氧化能力有望用于治疗神经疾病。
已进行了广泛研究以确立柚皮素在各个医学领域的抗炎、免疫调节和神经保护特性，这证明了其药理效用。将柚皮素用作治疗剂的主要障碍仍然是缺乏体内数据。应努力使柚皮素的给药对患者友好、经济可行且技术先进。
