Department of Natural Products, National Institute of Pharmaceutical and Educational Research, Kolkata, India.
CSIR-Indian Institute of Chemical Biology, Jadavpur, Kolkata, India.
Mini Rev Med Chem. 2022;22(22):2820-2830. doi: 10.2174/1389557522666220513150907.
Plant derived natural products have multifaceted beneficial roles in human pathophysiology. Plant secondary metabolites have been used as an adjunct medicine for a long time and β- Glucogallin is one such pharmaceutically important plant derived natural product. Β-glucogallin (1-O-galloyl-β-d-glucopyranose), a plant-derived polyphenolic ester, is regarded as the primary metabolite in the biosynthesis of hydrolyzable tannins. It is majorly found in amla, pomegranate, strawberry etc. Owing to its free radical scavenging properties, β-glucogallin (BG) is believed to protect against several diseases like diabetes and related complications like retinopathy, glaucoma, inflammation, hepatic damage, skin damage from UV, etc. Several semisynthetic derivatives of β-Glucogallin are being developed, which have better pharmacokinetic and pharmacodynamic parameters than β-glucogallin. Studies have shown the prophylactic role of β-Glucogallin in developing defence mechanisms against the advent and progression of certain diseases. β- glucogallin formulations have shown a positive effect as a neutraceutical. In this manuscript, we have discussed β-glucogallin, its natural sources, biosynthetic pathways, its semi-synthetic derivatives, and the plethora of its pharmacological activities like antioxidant-antiinflammatory, antidiabetic, cataract-preventing, anti glaucoma, and UV protectant. We have also highlighted various biological pathways, which are modulated by β-glucogallin. The manuscript will convey the importance of β-glucogallin as a compound of natural origin, having multifaceted health benefits.
植物源性天然产物在人类病理生理学中具有多方面的有益作用。植物次生代谢产物长期以来一直被用作辅助药物，β-葡糖基gallin 就是一种具有重要药用价值的植物源性天然产物。β-葡糖基gallin（1-O-没食子酰基-β-D-吡喃葡萄糖），一种植物来源的多酚酯，被认为是水解单宁生物合成的主要代谢物。它主要存在于余甘子、石榴、草莓等中。由于其具有清除自由基的特性，β-葡糖基gallin（BG）被认为可以预防糖尿病等多种疾病及其相关并发症，如视网膜病变、青光眼、炎症、肝损伤、紫外线引起的皮肤损伤等。几种β-葡糖基gallin 的半合成衍生物正在开发中，它们具有比β-葡糖基gallin 更好的药代动力学和药效学参数。研究表明，β-葡糖基gallin 具有预防某些疾病发生和发展的防御机制的作用。β-葡糖基gallin 制剂已作为一种营养保健品显示出积极的效果。在本文中，我们讨论了β-葡糖基gallin 及其天然来源、生物合成途径、半合成衍生物，以及它在抗氧化-抗炎、抗糖尿病、白内障预防、抗青光眼和紫外线保护等方面的诸多药理学活性。我们还强调了β-葡糖基gallin 调节的各种生物学途径。本文将传达β-葡糖基gallin 作为一种具有多方面健康益处的天然来源化合物的重要性。
