Yuan Deqiang, Chu Jiapeng, Qian Jun, Lin Hao, Zhu Guoqi, Chen Fei, Liu Xuebo
Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, 200065 Shanghai, China.
Rev Cardiovasc Med. 2023 Apr 17;24(4):112. doi: 10.31083/j.rcm2404112. eCollection 2023 Apr.
Acute coronary syndrome (ACS) is the most severe form of ischemic heart disease. Although it is caused by atherosclerotic plaque thrombosis or nonatherosclerotic causes, its pathophysiological mechanism of ACS is not fully understood, and its concept is constantly updated and developed. At present, the main pathophysiological mechanisms include plaque rupture, plaque erosion, calcified nodules (CN) and non-atherosclerotic causes such as coronary vasospasm and myocardial bridging (MB). These mechanisms may overlap and coexist in some ACS patients. Therefore, the pathophysiological mechanism of ACS is complex, and is of great significance for the diagnosis and treatment of ACS. This review will discuss the pathophysiological mechanisms of ACS to provide new thoughts on the pathogenesis, diagnosis and treatment of ACS.
急性冠状动脉综合征（ACS）是缺血性心脏病最严重的形式。尽管它由动脉粥样硬化斑块血栓形成或非动脉粥样硬化原因引起，但其病理生理机制尚未完全阐明，其概念也在不断更新和发展。目前，主要的病理生理机制包括斑块破裂、斑块侵蚀、钙化结节（CN）以及冠状动脉痉挛和心肌桥（MB）等非动脉粥样硬化原因。这些机制在一些ACS患者中可能重叠并共存。因此，ACS的病理生理机制复杂，对ACS的诊断和治疗具有重要意义。本文综述将探讨ACS的病理生理机制，为ACS的发病机制、诊断和治疗提供新思路。
