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来自核糖体合成和翻译后修饰肽（RiPP）途径的甲基转移酶：塑造天然产物化学的格局

Methyltransferases from RiPP pathways: shaping the landscape of natural product chemistry.

作者信息

Schröder Maria-Paula, Pfeiffer Isabel P-M, Mordhorst Silja

机构信息

Pharmaceutical Institute, Department of Pharmaceutical Biology, University of Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany.

出版信息

Beilstein J Org Chem. 2024 Jul 18;20:1652-1670. doi: 10.3762/bjoc.20.147. eCollection 2024.

DOI:10.3762/bjoc.20.147
PMID:39076295
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11285071/
Abstract

This review article aims to highlight the role of methyltransferases within the context of ribosomally synthesised and post-translationally modified peptide (RiPP) natural products. Methyltransferases play a pivotal role in the biosynthesis of diverse natural products with unique chemical structures and bioactivities. They are highly chemo-, regio-, and stereoselective allowing methylation at various positions. The different possible acceptor regions in ribosomally synthesised peptides are described in this article. Furthermore, we will discuss the potential application of these methyltransferases as powerful biocatalytic tools in the synthesis of modified peptides and other bioactive compounds. By providing an overview of the various methylation options available, this review is intended to emphasise the biocatalytic potential of RiPP methyltransferases and their impact on the field of natural product chemistry.

摘要

这篇综述文章旨在强调甲基转移酶在核糖体合成及翻译后修饰肽（RiPP）类天然产物中的作用。甲基转移酶在具有独特化学结构和生物活性的多种天然产物的生物合成中起着关键作用。它们具有高度的化学、区域和立体选择性，能够在不同位置进行甲基化。本文描述了核糖体合成肽中不同的可能接受区域。此外，我们将讨论这些甲基转移酶作为强大的生物催化工具在合成修饰肽和其他生物活性化合物方面的潜在应用。通过概述可用的各种甲基化选择，本综述旨在强调RiPP甲基转移酶的生物催化潜力及其对天然产物化学领域的影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/833a323af9d4/Beilstein_J_Org_Chem-20-1652-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/d270bf93e074/Beilstein_J_Org_Chem-20-1652-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/404cbc993c51/Beilstein_J_Org_Chem-20-1652-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/5b057795e197/Beilstein_J_Org_Chem-20-1652-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/082fc2363312/Beilstein_J_Org_Chem-20-1652-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/9cc7cd6930d1/Beilstein_J_Org_Chem-20-1652-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/ae70719197e8/Beilstein_J_Org_Chem-20-1652-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/0eab1397d9d3/Beilstein_J_Org_Chem-20-1652-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/fe39a97f625b/Beilstein_J_Org_Chem-20-1652-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/afc92c166b02/Beilstein_J_Org_Chem-20-1652-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/833a323af9d4/Beilstein_J_Org_Chem-20-1652-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/d270bf93e074/Beilstein_J_Org_Chem-20-1652-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/404cbc993c51/Beilstein_J_Org_Chem-20-1652-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/5b057795e197/Beilstein_J_Org_Chem-20-1652-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/082fc2363312/Beilstein_J_Org_Chem-20-1652-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/9cc7cd6930d1/Beilstein_J_Org_Chem-20-1652-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/ae70719197e8/Beilstein_J_Org_Chem-20-1652-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/0eab1397d9d3/Beilstein_J_Org_Chem-20-1652-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/fe39a97f625b/Beilstein_J_Org_Chem-20-1652-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/afc92c166b02/Beilstein_J_Org_Chem-20-1652-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dbd3/11285071/833a323af9d4/Beilstein_J_Org_Chem-20-1652-g011.jpg

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Evolutionary Spread of Distinct O-methyltransferases Guides the Discovery of Unique Isoaspartate-Containing Peptides, Pamtides.独特的 O-甲基转移酶的进化传播指导了独特的含有异天冬氨酸肽（Pamtides）的发现。
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Characterization of the Biosynthetic Gene Cluster for the Ribosomally Synthesized Cyclic Peptide Epichloëcyclins in .内生真菌 Epichloë 中环肽 Epichloëcyclins 的生物合成基因簇的特性研究。
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