Zhang Jie, Yang Zhenhua, Fan Xiaoxiang, Fei Qiuping, Xi Yingfei
Department of Endocrinology, Ningbo No.2 Hospital, 315000 Ningbo, Zhejiang, China.
Rev Cardiovasc Med. 2024 Jun 4;25(6):207. doi: 10.31083/j.rcm2506207. eCollection 2024 Jun.
Patients with type 2 diabetes mellitus (T2DM) commonly exhibit overlooked left ventricular and atrial hypertrophy. This research identifies potential risk factors and intervention targets.
T2DM patients with normal ejection fraction values were enrolled, while we eliminated influences on heart size, such as hypertension and coronary heart disease. Variables for each participant, including height, weight, age, body mass index (BMI), and blood biochemistry, were recorded before patients were categorized into four groups based on heart size. Multiple linear regression and Pearson's correlation analyses were applied to investigate the possible correlations.
Three years of clinical data were collected for each T2DM patient, while patients with incomplete data or interference factors affecting heart size were excluded. BMI, adjusted fasting blood glucose (FBG), glomerular filtration rate (eGFR), and age all showed a significant positive correlation with the inner diameter of the left ventricle and atrium in groups exhibiting hypertrophy.
In T2DM patients, BMI correlated positively with left ventricular enlargement, suggesting its potential role as a risk factor. Weight control may be an effective intervention for left ventricular enlargement, to reduce the likelihood of heart failure.
2型糖尿病（T2DM）患者通常存在被忽视的左心室和心房肥大。本研究旨在确定潜在风险因素和干预靶点。
纳入射血分数正常的T2DM患者，同时排除高血压和冠心病等对心脏大小的影响因素。记录每位参与者的变量，包括身高、体重、年龄、体重指数（BMI）和血液生化指标，然后根据心脏大小将患者分为四组。应用多元线性回归和Pearson相关分析来研究可能的相关性。
收集了每位T2DM患者三年的临床数据，排除了数据不完整或存在影响心脏大小的干扰因素的患者。在出现肥大的组中，BMI、调整后的空腹血糖（FBG）、肾小球滤过率（eGFR）和年龄均与左心室和心房内径呈显著正相关。
在T2DM患者中，BMI与左心室扩大呈正相关，提示其可能作为一个风险因素。控制体重可能是对左心室扩大的有效干预措施，以降低心力衰竭的可能性。
