Department of Medical Genetics, School of Medicine, Mashhad University of Medical Sciences , Mashhad, Iran.
Golestan Rheumatology Research Center, Golestan University of Medical Sciences , Gorgan, Iran.
J Immunoassay Immunochem. 2020 Jul 3;41(4):768-777. doi: 10.1080/15321819.2020.1750423. Epub 2020 May 13.
Inflammation is a common feature of type 2 diabetes (T2D). Inflammatory cytokines increase in patients with type 2 diabetes, metabolic syndrome, and heart disease. Various types of cells can produce inflammatory cytokines and then release them into the bloodstream, where their complex interactions with target tissues raise a tissue-specific immune response. This review focused on C-reactive protein (CRP), tumor necrosis factor (TNF)-α as an inflammatory cytokine, and adiponectin produced by adipose tissues. Despite the major role of cytokines in the development of T2D, further studies are required to investigate the possible effects of the macronutrient composition of diet on these cytokines.
炎症是 2 型糖尿病(T2D)的常见特征。患有 2 型糖尿病、代谢综合征和心脏病的患者体内炎症细胞因子会增加。各种类型的细胞都可以产生炎症细胞因子,然后将其释放到血液中,在血液中它们与靶组织的复杂相互作用会引发组织特异性免疫反应。这篇综述重点介绍了 C 反应蛋白(CRP)、肿瘤坏死因子(TNF)-α 作为炎症细胞因子,以及脂肪组织产生的脂联素。尽管细胞因子在 T2D 的发展中起着重要作用,但仍需要进一步研究饮食中宏量营养素组成对这些细胞因子的可能影响。