Cao Mengying, Jiang Xueli, Wang Xiaolin, Gao Pan, Zou Yunzeng
Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 200032 Shanghai, China.
Institute of Biomedical Sciences, Fudan University, 200032 Shanghai, China.
Rev Cardiovasc Med. 2024 May 15;25(5):171. doi: 10.31083/j.rcm2505171. eCollection 2024 May.
Secreted frizzled-related protein 2 (sFRP2) is involved in various cardiovascular diseases. However, its relevance in left ventricular (LV) remodeling in patients with hypertension (HTN) is obscure.
In this study, 196 patients with HTN were included, 59 with echocardiographic LV remodeling. A total of 100 healthy subjects served as normal controls. The serum-sFRP2 level was measured by enzyme-linked immunosorbent assay (ELISA). Data were collected from medical records for baseline characteristics, biochemistry tests, and echocardiography. Receiver operating characteristic (ROC) curves were used to assess the distinguishing value of sFRP2 for LV remodeling in patients with HTN. Spearman rank correlation analysis was utilized to identify factors correlated with sFRP2. Cardiac sFRP2 was determined by Western blot and quantitative polymerase chain reaction (qPCR).
The level of serum-sFRP2 was higher in HTN patients with echocardiographic LV remodeling than their non-remodeling counterparts. ROC analysis showed that the area under the curve (AUC) for sFRP2 in distinguishing echocardiographic LV remodeling in HTN patients was 0.791 (95% confidence interval (CI): 0.714-0.869). The sFRP2 was negatively correlated with LV dimension and positively correlated with relative wall thickness (RWT). The expression of sFRP2 was higher in hypertrophic hearts, which could be reversed by myricetin.
The serum level and cardiac sFRP2 increased in the setting of LV remodeling and decreased by myricetin. Serum sFRP2 may be a promising distinguishing factor for LV remodeling in HTN patients.
分泌型卷曲相关蛋白2（sFRP2）参与多种心血管疾病。然而，其在高血压（HTN）患者左心室（LV）重构中的相关性尚不清楚。
本研究纳入196例HTN患者，其中59例有超声心动图显示的LV重构。共100名健康受试者作为正常对照。采用酶联免疫吸附测定（ELISA）法测定血清sFRP2水平。从病历中收集基线特征、生化检查和超声心动图数据。采用受试者操作特征（ROC）曲线评估sFRP2对HTN患者LV重构的鉴别价值。利用Spearman等级相关分析确定与sFRP2相关的因素。通过蛋白质印迹法和定量聚合酶链反应（qPCR）测定心脏sFRP2。
有超声心动图显示LV重构的HTN患者血清sFRP2水平高于无重构的患者。ROC分析显示，sFRP2在鉴别HTN患者超声心动图LV重构中的曲线下面积（AUC）为0.791（95%置信区间（CI）：0.714 - 0.869）。sFRP2与LV内径呈负相关，与相对室壁厚度（RWT）呈正相关。sFRP2在肥厚心脏中的表达较高，杨梅素可使其逆转。
在LV重构情况下，血清水平和心脏sFRP2升高，杨梅素可使其降低。血清sFRP2可能是HTN患者LV重构的一个有前景的鉴别因素。
