Yu Yiming, Ge Xiao, Cao Lifang, Li Feng
Department of General Practice, The First Affiliated Hospital of Weifang Medical University, Weifang People's Hospital, 261041 Weifang, Shandong, China.
Rev Cardiovasc Med. 2024 May 20;25(5):178. doi: 10.31083/j.rcm2505178. eCollection 2024 May.
The pathogenesis and development of chronic heart failure (CHF) may involve long non-coding ribonucleic acid (lncRNA) steroid receptor RNA activator 1 (SRA1), a known cardiomyopathy risk factor and regulator of cardiac myofibroblast activation. This study aimed to investigate the application of SRA1 in the early detection and prediction of CHF.
SRA1 plasma expression was determined in CHF patients and healthy individuals/using real time-quantitative polymerase chain reaction (RT-qPCR). The diagnostic and prognostic value of SRA1 was assessed using receiver operating curve (ROC) and Cox regression analyses.
Compared with the healthy controls, the patients with CHF had increased brain natriuretic peptide (BNP) levels, left atrial end-systolic diameter (LAD), left ventricular end-diastolic diameter (LVDd), and decreased left ventricular ejection fraction (LVEF). SRA1 was significantly upregulated in CHF patients as well as positively correlated with BNP level, LAD, and LVDd, and negatively correlated with LVEF. SRA1 could sensitively discriminate CHF patients from healthy individuals and was an independent predictor of adverse event-free survival in CHF patients.
Upregulated plasma SRA1 can discriminate patients with CHF from healthy individuals and predict adverse outcomes in CHF patients. Thus, SRA1 is a potential molecular indicator for monitoring chronic heart failure development.
慢性心力衰竭（CHF）的发病机制和发展可能涉及长链非编码核糖核酸（lncRNA）类固醇受体RNA激活剂1（SRA1），它是一种已知的心肌病风险因素和心肌成纤维细胞激活的调节因子。本研究旨在探讨SRA1在CHF早期检测和预测中的应用。
采用实时定量聚合酶链反应（RT-qPCR）测定CHF患者和健康个体血浆中SRA1的表达。使用受试者工作特征曲线（ROC）和Cox回归分析评估SRA1的诊断和预后价值。
与健康对照组相比，CHF患者的脑钠肽（BNP）水平、左心房收缩末期内径（LAD）、左心室舒张末期内径（LVDd）升高，左心室射血分数（LVEF）降低。SRA1在CHF患者中显著上调，并且与BNP水平、LAD和LVDd呈正相关，与LVEF呈负相关。SRA1能够灵敏地区分CHF患者和健康个体，并且是CHF患者无不良事件生存的独立预测因子。
血浆SRA1上调可区分CHF患者和健康个体，并预测CHF患者的不良结局。因此，SRA1是监测慢性心力衰竭发展的潜在分子指标。
