肝脏提取物介导的丙烯腈致突变性。
Liver extract mediated mutagenicity of acrylonitrile.
作者信息
De Meester C, Duverger-Van Bogaert M, Lambotte-Vandepaer M, Roberfroid M, Poncelet F, Mercier M
出版信息
Toxicology. 1979 May;13(1):7-15.
The mutagenic activity of acrylonitrile vapours towards Salmonella typhimurium strains strictly depends upon the presence of a liver postmitochondrial fraction. The reversion rate varies according to the animal species from which the S9 fraction is obtained as well as to the pretreatment of the animals. The comparatively weak activating effect of the microsomal fraction and the inability of both SKF525A and carbon monoxide to inhibit the S9 mediated mutagenicity of acrylonitrile (ACN) suggest that the cytochrome P-450-dependent monooxygenases do not play a major role in the metabolic activation of ACN into a mutagenic intermediate (s).
丙烯腈蒸汽对鼠伤寒沙门氏菌菌株的诱变活性严格取决于肝线粒体后成分的存在。回复突变率会因获取S9成分的动物物种以及动物的预处理方式而有所不同。微粒体成分的激活作用相对较弱，以及SKF525A和一氧化碳均无法抑制S9介导的丙烯腈（ACN）诱变活性，这表明细胞色素P-450依赖性单加氧酶在将ACN代谢活化为诱变中间体的过程中并不起主要作用。
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