血清1,5-脱水葡萄糖醇水平在急性心肌梗死患者中的预后价值

Prognostic Value of Serum 1,5-anhydroglucitol Levels in Patients with Acute Myocardial Infarction.

作者信息

Wang Yijia, Yang Ruiyue, Zhang Yanan, Wang Zhe, Wang Xinyue, Wang Siming, Zhang Wenduo, Yu Xue, Dong Jun, Chen Wenxiang, Ji Fusui

机构信息

Department of Cardiology, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, 100730 Beijing, China.

Chinese Academy of Medical Sciences and Graduate school of Peking Union Medical College, 100730 Beijing, China.

出版信息

Rev Cardiovasc Med. 2022 Dec 2;23(12):394. doi: 10.31083/j.rcm2312394. eCollection 2022 Dec.

DOI:10.31083/j.rcm2312394

PMID:39076658

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11270454/

Abstract

BACKGROUND

Diabetes mellitus is a major risk element for cardiovascular disease. In the present study we investigated whether 1,5-anhydroglucitol (1,5-AG), a new marker for glucose monitoring, can predict patient outcome following acute myocardial infarction (AMI).

METHODS

A total of 270 AMI patients who underwent coronary angiography (CAG) at Beijing Hospital from March 2017 to 2020 were enrolled in this prospective cohort study. The serum 1,5-AG concentration and biochemical indicators were evaluated prior to CAG. Cox regression analysis was used to investigate the relationship between 1,5-AG levels and major adverse cardiovascular and cerebrovascular events (MACCEs), and with all-cause mortality.

RESULTS

During the median follow-up period of 44 months, 49 MACCEs occurred and 33 patients died. The 1,5-AG level was significantly lower in the MACCEs group than in the MACCEs-free group ( = 0.001). Kaplan-Meier analysis also revealed that low 1,5-AG levels were associated with MACCEs ( 0.001) and with all-cause mortality ( = 0.001). Multivariate analysis showed that low 1,5-AG ( 8.8 g/mL) was an independent predictor of MACCEs (hazard ratio (HR) 2.000, 95% confidence interval (CI): 1.047-3.821, = 0.036). However, 1,5-AG was not a significant predictor for all-cause mortality in AMI patients ( 0.05).

CONCLUSIONS

Low 1,5-AG levels can predict MACCEs in AMI patients, but not all-cause mortality.

CLINICAL TRIAL REGISTRATION

NCT03072797.

摘要

背景

糖尿病是心血管疾病的主要危险因素。在本研究中，我们调查了一种用于血糖监测的新标志物1,5-脱水葡萄糖醇（1,5-AG）是否能够预测急性心肌梗死（AMI）患者的预后。

方法

本前瞻性队列研究纳入了2017年3月至2020年在北京医院接受冠状动脉造影（CAG）的270例AMI患者。在进行CAG之前评估血清1,5-AG浓度和生化指标。采用Cox回归分析来研究1,5-AG水平与主要不良心血管和脑血管事件（MACCEs）以及全因死亡率之间的关系。

结果

在44个月的中位随访期内，发生了49例MACCEs，33例患者死亡。MACCEs组的1,5-AG水平显著低于无MACCEs组（P = 0.001）。Kaplan-Meier分析还显示，低1,5-AG水平与MACCEs（P < 0.001）和全因死亡率（P = 0.001）相关联。多因素分析表明，低1,5-AG（< 8.8 μg/mL）是MACCEs的独立预测因子（风险比（HR）2.000，95%置信区间（CI）：1.047 - 3.821，P = 0.036）。然而，1,5-AG并非AMI患者全因死亡率的显著预测因子（P > 0.05）。