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脂质亚组分在动脉粥样硬化斑块形成中的作用。

The Role of Lipid Subcomponents in the Development of Atherosclerotic Plaques.

作者信息

Nie Lei, Xiang Xuying, Wen Cheng, Zhang Feng, Xia Yuanpeng, Wang Yong, Mao Ling

机构信息

Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, China.

出版信息

Rev Cardiovasc Med. 2023 May 5;24(5):139. doi: 10.31083/j.rcm2405139. eCollection 2023 May.

DOI:10.31083/j.rcm2405139
PMID:39076730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11273020/
Abstract

Atherosclerosis (AS) is a long-standing cardiovascular and cerebrovascular disease. Its occurrence and development are related to the pathophysiology of lipids including cholesteryl ester (CE), cholesterol, triacylglycerol (TG), and phospholipid (PL). In this review, we focus on the roles and possible mechanisms of different lipid subcomponents in the process of AS, and provide new ideas for the prevention, diagnosis and treatment of AS.

摘要

动脉粥样硬化(AS)是一种长期的心血管和脑血管疾病。其发生和发展与包括胆固醇酯(CE)、胆固醇、甘油三酯(TG)和磷脂(PL)在内的脂质病理生理学有关。在本综述中,我们重点关注不同脂质亚组分在AS过程中的作用及可能机制,并为AS的预防、诊断和治疗提供新思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdd3/11273020/2a9ba064e5b3/2153-8174-24-5-139-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdd3/11273020/245c2b0a47f4/2153-8174-24-5-139-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdd3/11273020/dec2f8626c40/2153-8174-24-5-139-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdd3/11273020/2a9ba064e5b3/2153-8174-24-5-139-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdd3/11273020/245c2b0a47f4/2153-8174-24-5-139-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdd3/11273020/dec2f8626c40/2153-8174-24-5-139-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fdd3/11273020/2a9ba064e5b3/2153-8174-24-5-139-g3.jpg

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本文引用的文献

1
Comparative lipid profiling of murine and human atherosclerotic plaques using high-resolution MALDI MSI.使用高分辨率 MALDI MSI 对鼠与人动脉粥样硬化斑块的脂质分布进行比较分析。
Pflugers Arch. 2022 Feb;474(2):231-242. doi: 10.1007/s00424-021-02643-x. Epub 2021 Nov 19.
2
The Initial Human Atherosclerotic Lesion and Lipoprotein Modification-A Deep Connection.初始动脉粥样硬化病变与脂蛋白修饰——深层次关联
Int J Mol Sci. 2021 Oct 25;22(21):11488. doi: 10.3390/ijms222111488.
3
Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS).
老年人血清非酯化脂肪酸、颈动脉内膜中层厚度和血流介导的扩张:心血管健康研究(CHS)。
Nutrients. 2021 Aug 31;13(9):3052. doi: 10.3390/nu13093052.
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Lipid Metabolism.脂质代谢
Cold Spring Harb Perspect Biol. 2021 Sep 1;13(9):a040576. doi: 10.1101/cshperspect.a040576.
5
Lipid profiles of patients with manifest coronary versus peripheral atherosclerosis - Is there a difference?有明显冠状动脉粥样硬化与外周动脉粥样硬化患者的血脂谱——有差异吗?
J Intern Med. 2021 Dec;290(6):1249-1263. doi: 10.1111/joim.13368. Epub 2021 Sep 10.
6
Lysophosphatidylcholine induces oxidative stress in human endothelial cells via NOX5 activation - implications in atherosclerosis.溶血磷脂酰胆碱通过激活 NOX5 诱导人内皮细胞氧化应激 - 在动脉粥样硬化中的意义。
Clin Sci (Lond). 2021 Aug 13;135(15):1845-1858. doi: 10.1042/CS20210468.
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Cholesterol efflux pathways, inflammation, and atherosclerosis.胆固醇外排途径、炎症与动脉粥样硬化。
Crit Rev Biochem Mol Biol. 2021 Aug;56(4):426-439. doi: 10.1080/10409238.2021.1925217. Epub 2021 Jun 28.
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Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis.抑制肠道法尼醇 X 受体/鞘磷脂磷酸二酯酶 3 轴可减少动脉粥样硬化。
J Clin Invest. 2021 May 3;131(9). doi: 10.1172/JCI142865.
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Mass Spectrometry Imaging as a Tool to Investigate Region Specific Lipid Alterations in Symptomatic Human Carotid Atherosclerotic Plaques.质谱成像作为一种研究有症状的人类颈动脉粥样硬化斑块中区域特异性脂质改变的工具。
Metabolites. 2021 Apr 18;11(4):250. doi: 10.3390/metabo11040250.
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