Chaulin Aleksey
Department of Histology and Embryology, Samara State Medical University, 443099 Samara, Samara Region, Russia.
Department of Cardiology and Cardiovascular Surgery, Samara State Medical University, 443099 Samara, Samara Region, Russia.
Rev Cardiovasc Med. 2023 Jan 11;24(1):22. doi: 10.31083/j.rcm2401022. eCollection 2023 Jan.
According to current views, statins have a wide range of beneficial effects (lipid and non-lipid) on the cardiovascular system, so they are one of the most commonly used drugs for the prevention and management of patients with cardiovascular diseases. However, it is important to note that information about many beneficial effects of statins is contradictory. In addition, a number of side effects of statins, in particular, myotoxicity, hepatotoxicity, diabetogenic property, etc., may limit the possibility of using statins or even force doctors to cancel these drugs. Also, some concerns are caused by recent studies reporting cardiotoxicity of statins and increased serum concentrations of biomarkers of myocardial damage (highly sensitive cardiac troponins (hs-cTns)) in patients taking statins. This article discusses in detail the possible mechanisms of cardiotoxicity of statins and outlines the directions for further research in this area.
根据目前的观点，他汀类药物对心血管系统具有广泛的有益作用（脂质和非脂质方面），因此它们是预防和治疗心血管疾病患者最常用的药物之一。然而，需要注意的是，关于他汀类药物许多有益作用的信息相互矛盾。此外，他汀类药物的一些副作用，特别是肌毒性、肝毒性、致糖尿病特性等，可能会限制使用他汀类药物的可能性，甚至迫使医生停用这些药物。另外，最近的研究报告称他汀类药物具有心脏毒性，且服用他汀类药物的患者心肌损伤生物标志物（高敏心肌肌钙蛋白（hs-cTns））的血清浓度升高，这也引发了一些担忧。本文详细讨论了他汀类药物心脏毒性的可能机制，并概述了该领域进一步研究的方向。
