Díez-Villanueva Pablo, Jiménez-Méndez César, Ferreiro José Luis, Cepas-Guillén Pedro, Bonanad Clara, García-Blas Sergio, Ariza-Solé Albert, Sanchís Juan, Martínez-Sellés Manuel
Cardiology Department, Hospital Universitario La Princesa, 28006 Madrid, Spain.
Cardiology Department, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain.
Rev Cardiovasc Med. 2023 Jul 13;24(7):201. doi: 10.31083/j.rcm2407201. eCollection 2023 Jul.
Non-ST segment elevation myocardial infarction (NSTEMI) is the most frequent type of acute coronary syndrome in the elderly. Antithrombotic therapy is the cornerstone of pharmacological therapy in the setting of an acute ischemic event, a clinical scenario in which thrombotic and bleeding risks ought to be considered, particularly in older patients. In this article, specific aspects of antithrombotic therapy in elderly patients with NSTEMI are reviewed, including pharmacokinetic and pharmacodynamic characteristics and different clinical situations. The role of frailty and other common geriatric conditions, that are associated with worse prognosis in elderly patients with cardiovascular disease, is also addressed.
非ST段抬高型心肌梗死（NSTEMI）是老年人中最常见的急性冠状动脉综合征类型。抗栓治疗是急性缺血事件药物治疗的基石，在这种临床情况下，应考虑血栓形成和出血风险，尤其是在老年患者中。本文回顾了老年NSTEMI患者抗栓治疗的具体方面，包括药代动力学和药效学特征以及不同的临床情况。还讨论了衰弱和其他常见老年疾病在老年心血管疾病患者中与预后较差相关的作用。
