Ivanova E V, Fraĭkin G Ia
Biokhimiia. 1985 Aug;50(8):1374-6.
Using two-dimensional thin-layer chromatography, the effect of serotonin on the yield of thymine dimers and on cleavage of the N-glycosidic bond in the DNA irradiated with ultraviolet (UV) light and X-ray was studied. Bound serotonin was shown to reduce the synthesis of UV-induced thymine dimers but had no effect on the number of X-ray-induced breaks in the N-glycoside bonds in thymidine residues. The data obtained are discussed in terms of the mechanisms of serotonin involvement in the photoprotection of yeast cells from the lethal action of UV and X-ray irradiations.
利用二维薄层色谱法，研究了血清素对紫外线（UV）和X射线照射的DNA中胸腺嘧啶二聚体产量以及N-糖苷键断裂的影响。结果表明，结合态血清素可减少紫外线诱导的胸腺嘧啶二聚体的合成，但对胸苷残基中X射线诱导的N-糖苷键断裂数量没有影响。根据血清素参与酵母细胞免受紫外线和X射线照射致死作用的光保护机制，对所获得的数据进行了讨论。
