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[光诱导合成血清素对酿酒酵母光复活的影响]

[Effect of the photo-induced synthesis of serotonin on the photoreactivation of Saccharomyces cerevisiae yeasts].

作者信息

Strakhovskaia M G, Serdalina A M, Fraĭkin G Ia

出版信息

Nauchnye Doki Vyss Shkoly Biol Nauki. 1983(3):25-8.

PMID:6342686
Abstract

The photoreactivation of yeast (Saccharomyces cerevisiae) cells irradiated by far-UV-light has been studied. It has been shown that the near-UV-induced (334, 365 nm) synthesis of serotonin in yeast is an underlying cause of its photoreactivation action spectrum change. The effect of serotonin is due to its binding to far-UV-irradiated DNA (pyrimidine dimers) making them unavailable to the photoreactivating enzyme. The data obtained support the idea that serotonin affects the repair enzymes which are engaged in an elimination of lethal photoproducts from DNA.

摘要

对经远紫外线照射的酵母(酿酒酵母)细胞的光复活作用进行了研究。结果表明,酵母中近紫外线诱导(334、365纳米)的血清素合成是其光复活作用光谱变化的根本原因。血清素的作用是由于它与经远紫外线照射的DNA(嘧啶二聚体)结合,使它们无法被光复活酶作用。所获得的数据支持了血清素影响参与从DNA中消除致死性光产物的修复酶这一观点。

相似文献

1
[Effect of the photo-induced synthesis of serotonin on the photoreactivation of Saccharomyces cerevisiae yeasts].[光诱导合成血清素对酿酒酵母光复活的影响]
Nauchnye Doki Vyss Shkoly Biol Nauki. 1983(3):25-8.
2
[Role of DNA damage in the inactivation of Saccharomyces cerevisiae yeasts by 313-nm ultraviolet light].[DNA损伤在313纳米紫外线对酿酒酵母的灭活作用中的角色]
Nauchnye Doki Vyss Shkoly Biol Nauki. 1984(1):35-7.
3
[Concurrent effect of ultraviolet rays of various wave lengths on Saccharomyces cerevisiae survival].[不同波长紫外线对酿酒酵母存活率的协同作用]
Mikrobiologiia. 1982;51(5):761-4.
4
TATA-binding protein promotes the selective formation of UV-induced (6-4)-photoproducts and modulates DNA repair in the TATA box.TATA 结合蛋白促进紫外线诱导的(6-4)光产物的选择性形成,并调节 TATA 框中的 DNA 修复。
EMBO J. 1999 Jan 15;18(2):433-43. doi: 10.1093/emboj/18.2.433.
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In UV-irradiated Saccharomyces cerevisiae, overexpression of Swi2/Snf2 family member Rad26 increases transcription-coupled repair and repair of the non-transcribed strand.在紫外线照射的酿酒酵母中,Swi2/Snf2家族成员Rad26的过表达增加了转录偶联修复以及非转录链的修复。
Mol Microbiol. 2004 Jun;52(6):1653-63. doi: 10.1111/j.1365-2958.2004.04081.x.
6
Is DNA damage the signal for induction of thermal resistance? induction by radiation in yeast.DNA损伤是诱导耐热性的信号吗?酵母中辐射诱导的情况。
Radiat Res. 1984 Aug;99(2):383-93.
7
The Saccharomyces cerevisiae histone acetyltransferase Gcn5 has a role in the photoreactivation and nucleotide excision repair of UV-induced cyclobutane pyrimidine dimers in the MFA2 gene.酿酒酵母组蛋白乙酰转移酶Gcn5在MFA2基因中紫外线诱导的环丁烷嘧啶二聚体的光复活和核苷酸切除修复中发挥作用。
J Mol Biol. 2002 Feb 22;316(3):489-99. doi: 10.1006/jmbi.2001.5383.
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[Photoprotection in Saccharomyces cerevisiae yeasts from the lethal action of ultraviolet light at 254 and 313 nm].[酿酒酵母对254和313纳米紫外线致死作用的光保护]
Dokl Akad Nauk SSSR. 1981;261(5):1257-9.
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[Serotonin inhibition of photoenzymatic decomposition of thymine dimers in DNA].[血清素对DNA中胸腺嘧啶二聚体光酶促分解的抑制作用]
Izv Akad Nauk SSSR Biol. 1988 Nov-Dec(6):936-9.
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[Lack of foto reactivation of the Haemophilus influenzae transforming DNA mutated with near ultraviolet light (325-400nm)].[用近紫外光(325 - 400纳米)诱变的流感嗜血杆菌转化DNA缺乏光复活作用]
Rev Latinoam Microbiol. 1993 Jul-Sep;35(3):259-65.

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