细胞外钾对胰腺β细胞振荡影响的理论
Theory of the effect of extracellular potassium on oscillations in the pancreatic beta-cell.
作者信息
Chay T R, Keizer J
出版信息
Biophys J. 1985 Nov;48(5):815-27. doi: 10.1016/S0006-3495(85)83840-6.
Abstract
Based on the observation that potassium ions are compartmentalized near the surface of pancreatic beta-cells in mouse islets (Perez-Armendariz, E.M., I. Atwater, and E. Rojas 1985, Biophys. J. 48:741-749), we present a theoretical treatment of the effect of external potassium on oscillations in the pancreatic beta-cell. Our model includes the effects of ionic diffusion, the Ca2+-activated K+ channel, voltage-gated K+ and Ca2+ channels, and some of the effects of glucose. It is described by four ordinary differential equations. Numerical integration of these equations allows us to examine the effect of glucose, external K+, quinine, and tetraethylammonium ion (TEA) on the oscillations in membrane potential, intracellular Ca2+, and compartmentalized K+. The results are in good agreement with experiment.
摘要
基于钾离子在小鼠胰岛中胰腺β细胞表面被分隔的观察结果（佩雷斯 - 阿门达里兹，E.M.，I. 阿特沃特，和E. 罗哈斯，1985年，《生物物理杂志》48:741 - 749），我们对细胞外钾对胰腺β细胞振荡的影响进行了理论分析。我们的模型包括离子扩散、Ca²⁺激活的K⁺通道、电压门控的K⁺和Ca²⁺通道的影响，以及葡萄糖的一些影响。它由四个常微分方程描述。这些方程的数值积分使我们能够研究葡萄糖、细胞外K⁺、奎宁和四乙铵离子（TEA）对膜电位、细胞内Ca²⁺和分隔的K⁺振荡的影响。结果与实验结果高度吻合。
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