残余胆固醇与淋巴细胞比值作为接受经皮冠状动脉介入治疗的不稳定型心绞痛患者预后的新预测指标。

Remnant Cholesterol to Lymphocyte Ratio as a New Predictor of Prognosis in Patients with Unstable Angina Undergoing Percutaneous Coronary Intervention.

作者信息

Xi Hui, Zhang Biyang, Sun Tienan, Zhang Jingrui, Lv Haichen

机构信息

Peking University International Hospital, 102218 Beijing, China.

Beijing Anzhen Hospital affiliated Capital Medical University, 100089 Beijing, China.

出版信息

Rev Cardiovasc Med. 2023 Feb 28;24(3):71. doi: 10.31083/j.rcm2403071. eCollection 2023 Mar.

DOI:10.31083/j.rcm2403071

PMID:39077478

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11264004/

Abstract

BACKGROUND

Inflammatory cells and remnant cholesterol (RC) play an important role in the development and progression of cardiovascular diseases. In order to understand their contribution to cardiovascular diseases, we proposed the RC to lymphocyte ratio (RCLR) that reflects the level of serum lipid and inflammation as a predictive indicator. In this study, we explored the correlation between RCLR and major adverse cardiovascular events (MACEs) in patients with unstable angina (UA) treated with percutaneous coronary intervention (PCI).

METHODS

RCLR was calculated by dividing RC by lymphocyte percentage. Patients were divided into four groups according to RCLR quartiles. The endpoint of the study was MACE, a composite endpoint including all-cause mortality, non-fatal myocardial infarction (MI), and ischemia‑driven revascularization. The multivariable Cox proportional hazard model was used to determine the exclusive effect of RCLR on MACE.

RESULTS

The study was conducted on 1092 patients with UA. The rate of MACE increased as RCLR quartiles increased (quartile 4 vs quartile 1: 40.9% vs 9.2%, 0.001). An adjustment for confounding variables revealed that an increase in the rate of MACE was directly proportional to RCLR (quartile 4 vs quartile 1: HR - 5.85 [95% CI, 3.77-9.08], 0.001, for trend 0.001).

CONCLUSIONS

RCLR independently correlated with the incidence of MACE in patients with UA treated with PCI.

摘要

背景

炎症细胞和残余胆固醇（RC）在心血管疾病的发生和发展中起重要作用。为了解它们对心血管疾病的影响，我们提出了反映血脂和炎症水平的RC与淋巴细胞比率（RCLR）作为预测指标。在本研究中，我们探讨了接受经皮冠状动脉介入治疗（PCI）的不稳定型心绞痛（UA）患者中RCLR与主要不良心血管事件（MACE）之间的相关性。

方法

RCLR通过RC除以淋巴细胞百分比来计算。根据RCLR四分位数将患者分为四组。研究终点为MACE，这是一个综合终点，包括全因死亡率、非致命性心肌梗死（MI）和缺血驱动的血运重建。采用多变量Cox比例风险模型来确定RCLR对MACE的独立影响。

结果

该研究共纳入1092例UA患者。随着RCLR四分位数的增加，MACE发生率升高（四分位数4与四分位数1：40.9%对9.2%，P<0.001）。对混杂变量进行校正后显示，MACE发生率的增加与RCLR成正比（四分位数4与四分位数1：HR = 5.85[95%CI，3.77 - 9.08]，P<0.001，趋势P<0.001）。