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心力衰竭靶向治疗的研究进展

Research Advances in Targeted Therapy for Heart Failure.

作者信息

Miao Liu, Liu Yan-Li

机构信息

Department of Cardiology, Liuzhou People's Hospital, Affiliated of Guangxi Medical University, 545006 Liuzhou, Guangxi, China.

出版信息

Rev Cardiovasc Med. 2023 Oct 7;24(10):276. doi: 10.31083/j.rcm2410276. eCollection 2023 Oct.

DOI:10.31083/j.rcm2410276
PMID:39077559
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11262442/
Abstract

Cardiovascular disease is one of the major diseases threatening the health of Chinese residents, and the death rate has long been the highest on the disease spectrum in China. With the progress of population aging, the prevalence and mortality of cardiovascular diseases remain on the rise, and the current treatment effect on and prognosis of heart failure (HF) are not satisfactory. It is particularly important to explore the potential pathogenic mechanisms of HF and identify new therapeutic targets.

摘要

心血管疾病是威胁中国居民健康的主要疾病之一,其死亡率长期以来在中国疾病谱中位居首位。随着人口老龄化进程的推进,心血管疾病的患病率和死亡率持续上升,目前针对心力衰竭(HF)的治疗效果和预后并不理想。探索HF的潜在致病机制并确定新的治疗靶点尤为重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0478/11262442/0a39e92088d0/2153-8174-24-10-276-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0478/11262442/0a39e92088d0/2153-8174-24-10-276-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0478/11262442/0a39e92088d0/2153-8174-24-10-276-g1.jpg

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Rev Cardiovasc Med. 2022 Feb 12;23(2):60. doi: 10.31083/j.rcm2302060.
2
Prognostic value of microRNAs in heart failure: A meta-analysis.miRNAs 在心力衰竭中的预后价值:一项荟萃分析。
Medicine (Baltimore). 2021 Nov 19;100(46):e27744. doi: 10.1097/MD.0000000000027744.
3
Berberine Promotes Cardiac Function by Upregulating PINK1/Parkin-Mediated Mitophagy in Heart Failure.
黄连素通过上调PINK1/Parkin介导的线粒体自噬促进心力衰竭时的心脏功能。
Front Physiol. 2020 Sep 25;11:565751. doi: 10.3389/fphys.2020.565751. eCollection 2020.
4
Inflammatory Cytokines and Chemokines as Therapeutic Targets in Heart Failure.炎症细胞因子和趋化因子作为心力衰竭的治疗靶点。
Cardiovasc Drugs Ther. 2020 Dec;34(6):849-863. doi: 10.1007/s10557-020-07071-0. Epub 2020 Sep 9.
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A PROTAC peptide induces durable β-catenin degradation and suppresses Wnt-dependent intestinal cancer.一种PROTAC肽可诱导持久的β-连环蛋白降解并抑制Wnt依赖性肠道癌。
Cell Discov. 2020 Jun 9;6:35. doi: 10.1038/s41421-020-0171-1. eCollection 2020.
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J Cardiovasc Transl Res. 2021 Feb;14(1):35-52. doi: 10.1007/s12265-020-10006-7. Epub 2020 May 15.
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