Department of Cardiovascular, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 16369, Jingshi Road, Jinan, China.
Department of Vascular Surgery, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Medicine (Baltimore). 2021 Nov 19;100(46):e27744. doi: 10.1097/MD.0000000000027744.
Reported studies have shown that expression levels of microRNAs (miRNAs) are related to survival time of patients with heart failure (HF). A systematic review and meta-analysis were conducted to study circulating miRNAs expression and patient outcome.
Meta-analysis estimating expression levels of circulating miRNAs in HF patients from January 2010 until June 30, 2018, through conducting online searches in Pub Med, Cochrane Database of Systematic, EMBASE and Web of Science and reviewed by 2 independent researchers. Using pooled hazard ratio with a 95% confidence interval to assess the correlation between miRNAs expression levels and overall survival.
Four relevant articles assessing 19 circulating miRNAs in 867 patients were included. In conclusion, the meta-analysis results suggest that HF patients with low expression of serum miR-1, miR-423-5p, miR-126, miR-21, miR-23, miR-30d, miR-18a-5p, miR-16-5p, miR-18b-5p, miR-27a-3p, miR-26b-5p, miR-30e-5p, miR-106a-5p, miR-233-3P, miR-301a-3p, miR-423-3P, and miR-128 have significantly worse overall survival (P < .05). Among them, miR-18a-5p, miR-18b-5p, miR-30d, miR-30e-5p, and miR-423-5p are strong biomarkers of prognosis in HF.
已有研究表明，微小 RNA（miRNA）的表达水平与心力衰竭（HF）患者的生存时间有关。本系统评价和荟萃分析旨在研究循环 miRNA 表达与患者预后的关系。
通过在 Pub Med、Cochrane 系统评价数据库、EMBASE 和 Web of Science 上在线搜索，对 2010 年 1 月至 2018 年 6 月 30 日发表的 HF 患者循环 miRNA 表达的研究进行荟萃分析，由 2 位独立研究人员进行评估。采用合并危险比（HR）及其 95%置信区间（CI）评估 miRNA 表达水平与总生存率之间的相关性。
纳入了 4 项评估 867 例患者 19 种循环 miRNA 的相关研究。荟萃分析结果表明，血清 miR-1、miR-423-5p、miR-126、miR-21、miR-23、miR-30d、miR-18a-5p、miR-16-5p、miR-18b-5p、miR-27a-3p、miR-26b-5p、miR-30e-5p、miR-106a-5p、miR-233-3P、miR-301a-3p、miR-423-3P 和 miR-128 低表达的 HF 患者总体生存率显著降低（P ＜.05）。其中，miR-18a-5p、miR-18b-5p、miR-30d、miR-30e-5p 和 miR-423-5p 是 HF 预后的强生物标志物。
