Yao Jiashu, Wang Shenpang, Li Yifei, Xu Jiating, Ye Ruihuan, Shen Yuedi, Chen Wei, Dai Ning
Department of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Department of Psychiatry, Shaoxing 7th People's Hospital, Shaoxing, Zhejiang, China.
Front Psychiatry. 2024 Jul 15;15:1411882. doi: 10.3389/fpsyt.2024.1411882. eCollection 2024.
Here we report on a case of a 61-year-old female patient with 7-year history of major depressive disorder with shorter-duration hypomanic episodes who was prescribed with antidepressants which turned out to be ineffective. After a COVID-19 infection, the patient's clinical presentation became sufficient for the diagnosis of bipolar disorder and she was consistently effective on a mood stabilizer and an atypical antipsychotic. The course of treatment in this case suggests bipolar disorder is not a binary disorder, but a continuous spectrum disorder. For patients suffering from major depressive disorder with shorter-duration hypomanic episodes, mood stabilizers and atypical antipsychotics are possibly more suitable than antidepressants.
在此，我们报告一例61岁女性患者，该患者患有重度抑郁症7年，伴有发作持续时间较短的轻躁狂发作，曾服用抗抑郁药，但结果无效。感染新型冠状病毒肺炎后，患者的临床表现足以诊断为双相情感障碍，并且她在服用心境稳定剂和非典型抗精神病药物后持续有效。该病例的治疗过程表明，双相情感障碍并非二元性疾病，而是一种连续谱系障碍。对于患有发作持续时间较短的轻躁狂发作的重度抑郁症患者，心境稳定剂和非典型抗精神病药物可能比抗抑郁药更合适。
