Wang Hui, Huang Zhongmin, Du Chenyan, Dong Mingqing
Geriatric Diseases Institute of Chengdu, Center for Medicine Research and Translation, Chengdu Fifth People's Hospital, 611137 Chengdu, Sichuan, China.
Rev Cardiovasc Med. 2024 Jan 10;25(1):16. doi: 10.31083/j.rcm2501016. eCollection 2024 Jan.
Iron metabolism plays a crucial role in various physiological functions of the human body, as it is essential for the growth and development of almost all organisms. Dysregulated iron metabolism-manifested either as iron deficiency or overload-is a significant risk factor for the development of cardiovascular disease (CVD). Moreover, emerging evidence suggests that ferroptosis, a form of iron-dependent programed cell death, may also contribute to CVD development. Understanding the regulatory mechanisms of iron metabolism and ferroptosis in CVD is important for improving disease management. By integrating different perspectives and expertise in the field of CVD-related iron metabolism, this overview provides insights into iron metabolism and CVD, along with approaches for diagnosing, treating, and preventing CVD associated with iron dysregulation.
铁代谢在人体的各种生理功能中起着至关重要的作用，因为它对几乎所有生物体的生长和发育都至关重要。铁代谢失调，表现为缺铁或铁过载，是心血管疾病（CVD）发生的一个重要危险因素。此外，新出现的证据表明，铁死亡，一种铁依赖性程序性细胞死亡形式，也可能促成CVD的发生。了解CVD中铁代谢和铁死亡的调节机制对于改善疾病管理很重要。通过整合CVD相关铁代谢领域的不同观点和专业知识，本综述提供了对铁代谢和CVD的见解，以及诊断、治疗和预防与铁失调相关的CVD的方法。
