Chen Peijian, He Ping, Rao Xuejing, Ding Minglu, Liu Jieting, Chu Yanhui, Xiao Yang
College of Life Sciences, Mudanjiang Medical University, Mudanjiang, 157011, China.
Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, 157011, China.
Mol Cell Biochem. 2025 Jun 23. doi: 10.1007/s11010-025-05340-w.
Cardiovascular diseases (CVDs) comprise a range of conditions affecting the heart and vasculature, encompassing ischemic heart disease (IHD), stroke, heart failure (HF), peripheral and aortic diseases, arrhythmias, and valvulopathy. Notably, the high prevalence rates of CVDs among younger populations warrant concern, emphasizing the importance of prevention and treatment. In recent years, ferroptosis, a novel form of cell death, has attracted significant research interest across various diseases. Similarly, cuproptosis, another cell death mechanism resulting from copper ion accumulation, has also been extensively studied. Cell death plays a crucial role in the development and maintenance of organisms, with both ferroptosis and cuproptosis closely associated with cell metabolism, signaling pathways, and drug resistance. Emerging evidence suggests that ferroptosis and cuproptosis are closely linked to the occurrence and progression of various diseases, including CVDs. The death of myocardial cells is pivotal in the pathophysiology of CVDs, with the roles of ferroptosis and cuproptosis in this process increasingly recognized. This article aims to summarize the molecular mechanisms and interactions of ferroptosis and cuproptosis, as well as their potential as novel targets for CVD treatment.
心血管疾病（CVDs）包括一系列影响心脏和血管系统的病症，涵盖缺血性心脏病（IHD）、中风、心力衰竭（HF）、外周血管疾病和主动脉疾病、心律失常以及瓣膜病。值得注意的是，CVDs在年轻人群中的高患病率值得关注，这凸显了预防和治疗的重要性。近年来，铁死亡作为一种新型细胞死亡形式，在各种疾病研究中引起了广泛关注。同样，铜死亡作为另一种由铜离子积累导致的细胞死亡机制，也得到了广泛研究。细胞死亡在生物体的发育和维持中起着至关重要的作用，铁死亡和铜死亡均与细胞代谢、信号通路及耐药性密切相关。新出现的证据表明，铁死亡和铜死亡与包括CVDs在内的各种疾病的发生和发展密切相关。心肌细胞死亡在CVDs的病理生理学中起关键作用，铁死亡和铜死亡在此过程中的作用日益受到认可。本文旨在总结铁死亡和铜死亡的分子机制及相互作用，以及它们作为CVD治疗新靶点的潜力。
