Department of Cardiology and Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
School of Pharmacy and Center for Cardiovascular Research and Alternative Medicine, University of Wyoming College of Health Sciences, Laramie, WY 82071, USA.
Biochem Pharmacol. 2021 Aug;190:114661. doi: 10.1016/j.bcp.2021.114661. Epub 2021 Jun 23.
Iron deficiency and iron overload are the most prevalent and opposite forms of dysregulated iron metabolism that affect approximately 30 percent of the world population, in particularly, elderly and patients with chronic diseases. Both iron deficiency and overload are frequently observed in a wide range of cardiovascular diseases, contributing to the onset and progression of these diseases. One of the devastating seqeulae for iron overload is the induction of ferroptosis, a newly defined form of regulated cell death which heavily impacts cardiac function through ferroptotic cell death in cardiomyocytes. In this review, we will aim to evaluate iron deficiency and iron overload in cardiovascular diseases. We will summarize current therapeutic strategies to tackle iron deficiency and iron overload, major pitfalls of current studies, and future perspectives.
缺铁和铁过载是最常见和相反的铁代谢失调形式，影响着全球约 30%的人口，特别是老年人和患有慢性病的患者。缺铁和铁过载在广泛的心血管疾病中都经常被观察到，这导致了这些疾病的发生和发展。铁过载的破坏性后果之一是诱导铁死亡，这是一种新定义的细胞死亡形式，通过心肌细胞的铁死亡对心脏功能产生重大影响。在这篇综述中，我们将评估铁缺乏和铁过载在心血管疾病中的作用。我们将总结目前治疗铁缺乏和铁过载的策略，讨论当前研究的主要缺陷，并展望未来的研究方向。
