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艾滋病患者西尼罗河病毒脑脊髓炎的灾难性病例。

Catastrophic Case of West Nile Virus Rhombencephalitis in AIDS.

机构信息

Kern Medical, Bakersfield, CA, USA.

David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

出版信息

J Investig Med High Impact Case Rep. 2024 Jan-Dec;12:23247096241267132. doi: 10.1177/23247096241267132.

DOI:10.1177/23247096241267132
PMID:39077811
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11289818/
Abstract

West Nile Virus (WNV) belongs to the Flaviviridae family of viruses. It was first isolated and identified in 1937. Patients typically present with flu-like symptoms or are asymptomatic; however, neuroinvasive West Nile can lead to significant neurological impairment. Herein presented is a catastrophic case of WNV rhombencephalitis in a male patient newly diagnosed with AIDS. This report sheds light on the potential for severe neurological complications in co-infected patients and emphasizes the importance of early recognition.

摘要

西尼罗河病毒(WNV)属于黄病毒科病毒。它于 1937 年首次被分离和鉴定。患者通常表现为流感样症状或无症状;然而,神经侵袭性西尼罗河可导致严重的神经损伤。本文介绍了一例新诊断为艾滋病的男性患者的西尼罗河菱形脑炎的灾难性病例。本报告阐明了合并感染患者发生严重神经并发症的可能性,并强调了早期识别的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d9a/11289818/c48942afd7ad/10.1177_23247096241267132-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d9a/11289818/9f2dc43b0863/10.1177_23247096241267132-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d9a/11289818/c48942afd7ad/10.1177_23247096241267132-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d9a/11289818/9f2dc43b0863/10.1177_23247096241267132-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7d9a/11289818/c48942afd7ad/10.1177_23247096241267132-fig2.jpg

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本文引用的文献

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Neuroinvasive West Nile virus infections after solid organ transplantation: Single center experience and systematic review.实体器官移植后神经侵袭性西尼罗河病毒感染:单中心经验和系统评价。
Transpl Infect Dis. 2022 Dec;24(6):e13929. doi: 10.1111/tid.13929. Epub 2022 Aug 30.
2
Management of West Nile Encephalitis: An Uncommon Complication of West Nile Virus.西尼罗河脑炎的管理:西尼罗河病毒的一种罕见并发症
Cureus. 2021 Feb 6;13(2):e13183. doi: 10.7759/cureus.13183.
3
West Nile Virus: An Update on Pathobiology, Epidemiology, Diagnostics, Control and "One Health" Implications.
西尼罗河病毒:病理生物学、流行病学、诊断、防控及“同一健康”影响的最新进展
Pathogens. 2020 Jul 19;9(7):589. doi: 10.3390/pathogens9070589.
4
Morbidity, mortality and long-term sequelae of West Nile virus disease in Québec.魁北克的西尼罗河病毒病的发病率、死亡率和长期后遗症。
Epidemiol Infect. 2018 May;146(7):867-874. doi: 10.1017/S0950268818000687. Epub 2018 Mar 28.
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The global ecology and epidemiology of West Nile virus.西尼罗河病毒的全球生态学与流行病学
Biomed Res Int. 2015;2015:376230. doi: 10.1155/2015/376230. Epub 2015 Mar 19.
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Doxycycline prophylaxis to reduce incident syphilis among HIV-infected men who have sex with men who continue to engage in high-risk sex: a randomized, controlled pilot study.多西环素预防措施以降低在持续进行高危性行为的男男性接触艾滋病毒感染者中梅毒的发病率:一项随机对照试验性研究。
Sex Transm Dis. 2015 Feb;42(2):98-103. doi: 10.1097/OLQ.0000000000000216.
7
Fatal neurological respiratory insufficiency is common among viral encephalitides.病毒性脑炎中常见致命性神经源性呼吸功能不全。
J Infect Dis. 2013 Aug 15;208(4):573-83. doi: 10.1093/infdis/jit186. Epub 2013 May 2.
8
Impact of rituximab-associated B-cell defects on West Nile virus meningoencephalitis in solid organ transplant recipients.利妥昔单抗相关 B 细胞缺陷对实体器官移植受者西尼罗河病毒脑膜脑炎的影响。
Clin Transplant. 2010 Mar-Apr;24(2):223-8. doi: 10.1111/j.1399-0012.2009.01044.x. Epub 2009 Aug 3.
9
Persistent West Nile virus associated with a neurological sequela in hamsters identified by motor unit number estimation.通过运动单位数量估计确定,持续性西尼罗河病毒与仓鼠的一种神经后遗症相关。
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10
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J Virol. 2006 Dec;80(24):12060-9. doi: 10.1128/JVI.01650-06. Epub 2006 Oct 11.