Canberra Hospital, ACT, Australia.
J Investig Med High Impact Case Rep. 2024 Jan-Dec;12:23247096241262702. doi: 10.1177/23247096241262702.
Dermatomyositis (DM) and polymyositis are idiopathic inflammatory myopathies (IIMs), most associated with solid organ malignancies, and less commonly hematological malignancies. We discuss a case of DM associated with diffuse large B-cell lymphoma, followed by a review of literature on the pathogenesis, clinical course, treatment, and prognosis. Various challenges with the diagnosis and management of underlying lymphoproliferative disorders (LPDs) in patients with IIM are discussed. The case demonstrates the importance of being vigilant of the association between IIM and LPD. Cancer screening in patients with IIM is discussed, including the recently published International Guideline for IIM-Associated Cancer Screening. More research is required to address knowledge gaps in cancer screening in IIM.
皮肌炎 (DM) 和多发性肌炎是特发性炎症性肌病 (IIM)，最常与实体器官恶性肿瘤相关，较少与血液系统恶性肿瘤相关。我们讨论了一例与弥漫性大 B 细胞淋巴瘤相关的 DM，随后对发病机制、临床病程、治疗和预后进行了文献复习。讨论了在 IIM 患者中诊断和管理潜在淋巴增殖性疾病 (LPD) 时面临的各种挑战。该病例说明了警惕 IIM 和 LPD 之间关联的重要性。讨论了 IIM 患者的癌症筛查问题，包括最近发表的 IIM 相关癌症筛查国际指南。需要进一步研究来解决 IIM 癌症筛查中的知识空白。
