Nogueiras-Álvarez Rita, Pérez Francisco Inés
Osakidetza Basque Health Service, Galdakao-Usansolo University Hospital, Basque Country Pharmacovigilance Unit, Galdakao, Bizkaia/Vizcaya, Spain.
Breast Cancer Research Group, Bioaraba Health Research Institute, Vitoria-Gasteiz, Araba/Álava, Spain.
Br J Clin Pharmacol. 2024 Oct;90(10):2483-2508. doi: 10.1111/bcp.16181. Epub 2024 Jul 30.
With the continuous development of genetics in healthcare, there has been a significant contribution to the development of precision medicine, which is ultimately aimed at improving the care of patients. Generally, drug treatments used in Oncology are characterized by a narrow therapeutic range and by their potential toxicity. Knowledge of pharmacogenomics and pharmacogenetics can be very useful in the area of Oncology, as they constitute additional tools that can help to individualize patients' treatment. This work includes a description of some genes that have been revealed to be useful in the field of Oncology, as they play a role in drug prescription and in the prediction of treatment response.
随着遗传学在医疗保健领域的不断发展，它对精准医学的发展做出了重大贡献，而精准医学的最终目标是改善患者护理。一般来说，肿瘤学中使用的药物治疗具有治疗范围窄和潜在毒性的特点。药物基因组学和药物遗传学知识在肿瘤学领域可能非常有用，因为它们构成了有助于实现患者个体化治疗的额外工具。这项工作包括对一些已被证明在肿瘤学领域有用的基因的描述，因为它们在药物处方和治疗反应预测中发挥作用。
