Roila F, Tonato M, Basurto C, Canaletti R, Morsia D, Passalacqua R, DiCostanzo F, Donati D, Colombo N, Ballatori E
Cancer Treat Rep. 1985 Dec;69(12):1353-7.
High-dose metoclopramide has been proposed as an effective antiemetic agent in patients treated with cisplatin. Its optimal dosage schedule, however, has not yet been completely defined. We report the results of a multicenter, double-blind, randomized clinical trial where the efficacy and safety of two fixed high-dose regimens of metoclopramide (60 and 120 mg, respectively) have been tested in 112 patients receiving cisplatin treatment. No statistically significant difference has been found between the two groups. In patients treated with cisplatin at doses greater than 100 mg/m2, the higher dose regimen seems more efficacious, but this result should be confirmed in a larger group of patients. Treatment was generally well-tolerated. However, a consistent percentage of patients (about 60%) still present with vomiting, and this makes further investigation necessary.
大剂量甲氧氯普胺已被提议作为顺铂治疗患者的一种有效止吐药。然而，其最佳给药方案尚未完全确定。我们报告了一项多中心、双盲、随机临床试验的结果，在112例接受顺铂治疗的患者中测试了两种固定大剂量甲氧氯普胺方案（分别为60毫克和120毫克）的疗效和安全性。两组之间未发现统计学上的显著差异。在接受剂量大于100毫克/平方米顺铂治疗的患者中，较高剂量方案似乎更有效，但这一结果应在更大规模的患者群体中得到证实。治疗总体耐受性良好。然而，仍有相当比例的患者（约60%）出现呕吐，这使得有必要进行进一步研究。
